海龟温度依赖性性别决定的分子和细胞机制。

IF 2.4 4区医学 Q2 DEVELOPMENTAL BIOLOGY

Sexual Development Pub Date : 2021-01-01 Epub Date: 2021-06-24 DOI:10.1159/000515296

Horacio Merchant-Larios, Verónica Díaz-Hernández, Diego Cortez

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引用次数: 5

摘要

在哺乳动物中发现，胎儿睾丸是雄性表型发育的必要条件，这一发现激发了研究努力，以阐明脊椎动物性腺性别决定和分化的机制。1966年的一项开创性研究表明，孵化温度对某些爬行动物的性表型有影响，这引发了人们对环境在性别决定中作为可塑性调节剂的作用的极大兴趣。一些龟类物种被用作动物模型来验证有关温度依赖性性别决定(TSD)机制的假设。这篇简短的综述旨在概述科学努力的历史，这些努力证实了我们目前对最先进的TSD的理解，并以龟种为参考。

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Molecular and Cellular Mechanisms Underlying Temperature-Dependent Sex Determination in Turtles.

The discovery in mammals that fetal testes are required in order to develop the male phenotype inspired research efforts to elucidate the mechanisms underlying gonadal sex determination and differentiation in vertebrates. A pioneer work in 1966 that demonstrated the influence of incubation temperature on sexual phenotype in some reptilian species triggered great interest in the environment's role as a modulator of plasticity in sex determination. Several chelonian species have been used as animal models to test hypotheses concerning the mechanisms involved in temperature-dependent sex determination (TSD). This brief review intends to outline the history of scientific efforts that corroborate our current understanding of the state-of-the-art in TSD using chelonian species as a reference.

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来源期刊

Sexual Development 生物-发育生物学

CiteScore

4.00

自引率

4.30%

发文量

审稿时长

>12 weeks

期刊介绍： Recent discoveries in experimental and clinical research have led to impressive advances in our knowledge of the genetic and environmental mechanisms governing sex determination and differentiation, their evolution as well as the mutations or endocrine and metabolic abnormalities that interfere with normal gonadal development. ‘Sexual Development’ provides a unique forum for this rapidly expanding field. Its broad scope covers all aspects of genetics, molecular biology, embryology, endocrinology, evolution and pathology of sex determination and differentiation in humans and animals. It publishes high-quality original research manuscripts, review articles, short reports, case reports and commentaries. An internationally renowned and multidisciplinary editorial team of three chief editors, ten prominent scientists serving as section editors, and a distinguished panel of editorial board members ensures fast and author-friendly editorial processing and peer reviewing.