脂滴与自噬体、溶酶体及其他降解小泡的接触

Kristina Drizyte-Miller, Micah B Schott, Mark A McNiven
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引用次数: 0

摘要

脂滴(LDs)是一种动态脂肪储存细胞器,很容易与许多细胞结构和细胞器发生相互作用。脂滴与自噬体、溶酶体、自溶酶体和晚期内体等降解囊泡的接触是脂滴的一个重要接触点。这些接触通过选择性地自噬 LD(即噬脂)或将细胞膜脂肪酶招募到 LD 表面(即脂肪分解)来支持脂质分解。然而,LD-自噬体接触还具有脂质分解以外的其他功能,包括为自噬体的生物生成提供脂质。在这篇综述中,我们将讨论 LD 与自噬体和其它降解细胞器接触的分子介质,以及这些接触点在健康和疾病中的多种细胞功能。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Lipid Droplet Contacts With Autophagosomes, Lysosomes, and Other Degradative Vesicles.

Lipid Droplet Contacts With Autophagosomes, Lysosomes, and Other Degradative Vesicles.

Lipid Droplet Contacts With Autophagosomes, Lysosomes, and Other Degradative Vesicles.

Lipid droplets (LDs) are dynamic fat-storage organelles that interact readily with numerous cellular structures and organelles. A prominent LD contact site is with degradative vesicles such as autophagosomes, lysosomes, autolysosomes, and late endosomes. These contacts support lipid catabolism through the selective autophagy of LDs (i.e., lipophagy) or the recruitment of cytosolic lipases to the LD surface (i.e., lipolysis). However, LD-autophagosome contacts serve additional functions beyond lipid catabolism, including the supply of lipids for autophagosome biogenesis. In this review, we discuss the molecular mediators of LD contacts with autophagosomes and other degradative organelles as well as the diverse cellular functions of these contact sites in health and disease.

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