银屑病关节炎常规临床实践的综合措施:英国多中心研究中缩短版本的测试。

Q2 Medicine

The Journal of rheumatology. Supplement Pub Date : 2021-06-01 DOI:10.3899/jrheum.201675

William Tillett, Oliver FitzGerald, Laura C Coates, Jon Packham, Deepak R Jadon, Marco Massarotti, Mel Brook, Suzanne Lane, Paul Creamer, Anna Antony, Eleanor Korendowych, Adwaye Rambojun, Neil J McHugh, Philip S Helliwell

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引用次数: 5

摘要

目的:探讨银屑病关节炎(PsA)综合测量方法的简化版，以供临床常规应用。方法:在英国一项多中心观察性研究中，对PsA患者连续3次随访的临床和患者报告的结果测量(PROMs)进行评估。使用PROMs开发了缩短版的银屑病关节炎疾病活动综合指数(CPDAI)和银屑病和银屑病关节炎研究与评估组(GRAPPA)复合运动(GRACE)测量方法，并针对28个关节的疾病活动评分(DAS28)、银屑病关节炎的综合疾病活动和患者指数数据常规评估(RAPID3)进行了测试。用t评分、标准化反应均值(SRM)和效应量(ES)检验疾病状态和反应性之间的区别。数据在GRAPPA 2020年年会上提交给成员，成员们对推荐的复合常规实践进行了投票。结果:GRACE、3视觉模拟量表(VAS)和4视觉模拟量表(VAS)的SRM分别为0.67、0.77和0.63,CPDAI和缩短CPDAI (sCPDAI)的SRM分别为0.54和0.55。缩短版GRACE的t评分从7.8分提高到8.7分(3VAS)和9.0分(4VAS)，但CPDAI/sCPDAI的t评分从6.8分和6.1分降低。3VAS和4VAS在所有测试中均优于sCPDAI、DAS28、银屑病关节炎疾病活动性和RAPID3。在成员中，60%的人同意VAS量表包含足够的信息来评估疾病和对治疗的反应，53%的人推荐4VAS用于常规护理，26%的人推荐3VAS，而21%的人不确定。结论。单独缩短GRACE到VAS评分增强了检测状态和反应的能力，并且具有所测试的复合措施的最佳性能特征。GRAPPA成员建议在观察和试验数据集中进一步测试3VAS和4VAS。

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Composite Measures for Routine Clinical Practice in Psoriatic Arthritis: Testing of Shortened Versions in a UK Multicenter Study.

Objective To test shortened versions of the psoriatic arthritis (PsA) composite measures for use in routine clinical practice. Methods Clinical and patient-reported outcome measures (PROMs) were assessed in patients with PsA at 3 consecutive follow-up visits in a UK multicenter observational study. Shortened versions of the Composite Psoriatic Arthritis Disease Activity Index (CPDAI) and Group for Research and Assessment of Psoriasis and Psoriatic Arthritis (GRAPPA) Composite Exercise (GRACE) measures were developed using PROMs and tested against the Disease Activity Score in 28 joints (DAS28), composite Disease Activity in Psoriatic Arthritis, and Routine Assessment of Patient Index Data (RAPID3). Discrimination between disease states and responsiveness were tested with the t-score, standardized response mean (SRM), and effect size (ES). Data were presented to members at the GRAPPA 2020 annual meeting and members voted on the recommended composite routine practice. Results The SRM for the GRACE, 3 visual analog scale (VAS), and 4VAS were 0.67, 0.77, and 0.63, respectively, and for CPDAI and shortened CPDAI (sCPDAI) were 0.54 and 0.55, respectively. Shortened versions of the GRACE increased the t-score from 7.8 to 8.7 (3VAS) and 9.0 (4VAS), but reduced the t-score in the CPDAI/sCPDAI from 6.8 and 6.1. The 3VAS and 4VAS had superior performance characteristics to the sCPDAI, DAS28, Disease Activity in Psoriatic Arthritis, and RAPID3 in all tests. Of the members, 60% agreed that the VAS scales contained enough information to assess disease and response to treatment, 53% recommended the 4VAS for use in routine care, and 26% the 3VAS, while leaving 21% undecided. Conclusion. Shortening the GRACE to VAS scores alone enhances the ability to detect status and responsiveness and has the best performance characteristics of the tested composite measures. GRAPPA members recommend further testing of the 3VAS and 4VAS in observational and trial datasets.

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来源期刊

The Journal of rheumatology. Supplement Medicine-Medicine (all)

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期刊介绍： The Journal of Rheumatology is a monthly international serial edited by Duncan A. Gordon, The Journal features research articles on clinical subjects from scientists working in rheumatology and related fields, as well as proceedings of meetings as supplements to regular issues. Highlights of our 36 years serving Rheumatology include: groundbreaking and provocative editorials such as "Inverting the Pyramid," renowned Pediatric Rheumatology, proceedings of OMERACT and the Canadian Rheumatology Association, Cochrane Musculoskeletal Reviews, and supplements on emerging therapies.