类风湿关节炎关节的适应性免疫。

IF 2.7 Q3 IMMUNOLOGY
Immunological Medicine Pub Date : 2022-03-01 Epub Date: 2021-05-30 DOI:10.1080/25785826.2021.1930371
Hisakata Yamada
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引用次数: 2

摘要

类风湿性关节炎(RA)是一种自身免疫性疾病,适应性免疫在其发病机制中起着重要作用。临床研究显示滑膜内B细胞浸润,尤其是异位淋巴样肿瘤,与疾病严重程度有关。滑膜中的一些B细胞分化为浆细胞,产生自身抗体,如抗瓜氨酸化蛋白抗体,另一些分化为效应B细胞,产生促炎细胞因子并表达RANKL。滑膜B细胞也可能是重要的抗原提呈细胞。滑膜T细胞参与诱导抗体产生以及局部炎症。前者涉及最近发现的CD4 T细胞亚群外周辅助性T细胞(Tph),其特征是PD-1的表达和CXCL13和IL-21的产生,而后者可能是由th1样CD4 T细胞亚群介导的,这些细胞亚群可以产生多种促炎细胞因子,包括IFN-γ、TNF-α和GM-CSF,并表达细胞毒性分子,如perforin、颗粒酶和颗粒蛋白。滑膜中的CD8 T细胞能够产生大量的IFN-γ。然而,这些淋巴细胞是否参与RA的发病机制仍有待证实。它们的抗原特异性也需要澄清。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Adaptive immunity in the joint of rheumatoid arthritis.

Adaptive immunity plays central roles in the pathogenesis of rheumatoid arthritis (RA), as it is regarded as an autoimmune disease. Clinical investigations revealed infiltrations of B cells in the synovium, especially those with ectopic lymphoid neogenesis, associate with disease severity. While some B cells in the synovium differentiate into plasma cells producing autoantibodies such as anti-citrullinated protein antibody, others differentiate into effector B cells producing proinflammatory cytokines and expressing RANKL. Synovial B cells might also be important as antigen-presenting cells. Synovial T cells are implicated in the induction of antibody production as well as local inflammation. In the former, a recently identified CD4 T cell subset, peripheral helper T (Tph), which is characterized by the expression of PD-1 and production of CXCL13 and IL-21, is implicated, while the latter might be mediated by Th1-like CD4 T cell subsets that can produce multiple proinflammatory cytokines, including IFN-γ, TNF-α, and GM-CSF, and express cytotoxic molecules, such as perforin, granzymes and granulysin. CD8 T cells in the synovium are able to produce large amount of IFN-γ. However, the involvement of those lymphocytes in the pathogenesis of RA still awaits verification. Their antigen-specificity also needs to be clarified.

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来源期刊
Immunological Medicine
Immunological Medicine Medicine-Immunology and Allergy
CiteScore
7.10
自引率
2.30%
发文量
19
审稿时长
19 weeks
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