爱泼斯坦-巴尔病毒:当前的问题和挑战

IF 4.7 Q1 VIROLOGY

Tumour Virus Research Pub Date : 2021-12-01 DOI:10.1016/j.tvr.2021.200218

Lori Frappier

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引用次数: 20

摘要

eb病毒(Epstein-Barr virus, EBV)感染了世界上大多数人，由于溶解性感染和多种潜伏性感染之间复杂的相互作用，EBV可终生存在。虽然EBV通常无症状，但它是几种癌症的病原体，与多发性硬化症有很强的相关性。EBV究竟是如何促进这些疾病的，以及为什么它们是感染的罕见后果，目前还不完全清楚。在这里，我将讨论目前关于EBV诱导疾病的观点，包括在潜伏感染背景下裂解蛋白表达的重要性，以及特定EBV变体在疾病诱导中的可能重要性。

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Epstein-Barr virus: Current questions and challenges

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Epstein-Barr virus: Current questions and challenges

Epstein-Barr virus (EBV) infects most people worldwide and persists for life due to complicated interplay between lytic infection and multiple types of latent infections. While usually asymptomatic, EBV is a causative agent in several types of cancer and has a strong association with multiple sclerosis. Exactly how EBV promotes these diseases and why they are rare consequences of infection are incompletely understood. Here I will discuss current ideas on disease induction by EBV, including the importance of lytic protein expression in the context of latent infection as well as the possible importance of specific EBV variants in disease induction.

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来源期刊

Tumour Virus Research Medicine-Infectious Diseases

CiteScore

6.50

自引率

2.30%

发文量

审稿时长

56 days