PIDDosome:中心体对DNA损伤反应的守护和备份。

IF 2.6 Q3 ONCOLOGY

Molecular and Cellular Oncology Pub Date : 2021-03-28 eCollection Date: 2021-01-01 DOI:10.1080/23723556.2021.1893625

Matteo Burigotto, Luca L Fava

引用次数: 6

摘要

PIDDosome是一种caspase -2激活平台，用于响应中心体扩增或基因毒性胁迫。我们最近发现，这两种刺激都依赖于ANKRD26(锚蛋白重复结构域蛋白26)介导的中心体PIDD1 (p53诱导的带有死亡结构域的蛋白)的定位，证明了这种细胞器是如何直接影响细胞命运的。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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The PIDDosome: centrosome guardian and backup on the DNA damage response.

The PIDDosome is a Caspase-2-activating platform assembling in response to centrosome amplification or genotoxic stress. We have recently shown that both stimuli depend on ANKRD26 (ankyrin repeat domain-containing protein 26)-mediated localization of PIDD1 (p53-inducible protein with death domain) at the centrosome, demonstrating how this organelle can directly influence cell fate.

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来源期刊

Molecular and Cellular Oncology Biochemistry, Genetics and Molecular Biology-Cancer Research

CiteScore

3.20

自引率

0.00%

发文量

期刊介绍： For a long time, solid neoplasms have been viewed as relatively homogeneous entities composed for the most part of malignant cells. It is now clear that tumors are highly heterogeneous structures that evolve in the context of intimate interactions between cancer cells and endothelial, stromal as well as immune cells. During the past few years, experimental and clinical oncologists have witnessed several conceptual transitions of this type. Molecular and Cellular Oncology (MCO) emerges within this conceptual framework as a high-profile forum for the publication of fundamental, translational and clinical research on cancer. The scope of MCO is broad. Submissions dealing with all aspects of oncogenesis, tumor progression and response to therapy will be welcome, irrespective of whether they focus on solid or hematological neoplasms. MCO has gathered leading scientists with expertise in multiple areas of cancer research and other fields of investigation to constitute a large, interdisciplinary, Editorial Board that will ensure the quality of articles accepted for publication. MCO will publish Original Research Articles, Brief Reports, Reviews, Short Reviews, Commentaries, Author Views (auto-commentaries) and Meeting Reports dealing with all aspects of cancer research.