COVID-19神经系统损害:文献综述

Journal of Neurology Research Pub Date : 2020-10-01 Epub Date: 2020-09-04 DOI:10.14740/jnr619
Leonardo Jardim Vaz de Mello, Emylle Guimaraes Silva, Gabriel Oliveira Correa Rabelo, Mariana Evaristo Leite, Nathalia Ramos Vieira, Maryam Bahadori, Ali Seifi, Daniel Agustin Godoy
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引用次数: 8

摘要

由一种新型冠状病毒——严重急性呼吸综合征冠状病毒2 (SARS-CoV-2)引起的2019冠状病毒病(COVID-19)与许多神经系统症状有关。本文的目的是描述迄今为止报道的神经学表现及其可能的发病机制。我们使用“COVID-19”、“COVID”、“神经学”、“神经学”、“表现”、“影响”、“格林-巴利综合征”、“脑病”等术语对EMBASE、MEDLINE和SCIELO数据库进行了文献综述。共选择临床系列、回顾性研究和病例报告等33篇文章进行全面审查,以描述COVID-19的神经学表现。SARS-CoV-2感染有几种不同临床表现、严重程度和流行程度的神经学表现。最关键的疾病,如脑血管病、脑病和格林-巴利综合征,不太常见,通常与既往病史、已知的脑血管疾病危险因素或高龄有关。病毒传播的主要假设是通过血液途径或筛骨筛网板或细胞因子风暴引起的播散性严重免疫反应。与实验室检查改变相关的神经系统障碍的存在是医生及时识别SARS-CoV-2神经系统表现的重要线索。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Neurologic Compromise in COVID-19: A Literature Review.

Neurologic Compromise in COVID-19: A Literature Review.

Neurologic Compromise in COVID-19: A Literature Review.

Coronavirus disease 2019 (COVID-19) disease caused by a new coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has been associated with many neurological symptoms. The purpose of this article is to describe the neurological manifestations so far reported and their probable pathogenesis. We conducted a literature review on EMBASE, MEDLINE and SCIELO databases using the terms "COVID-19", "COVID", "neurological", "neurologic", "manifestations", "implications", "Guillain-Barre syndrome", "encephalopathy". A total of 33 articles including clinical series, retrospective studies, and case reports were selected and thoroughly reviewed to describe neurological manifestations of COVID-19. There are several neurological manifestations of SARS-CoV-2 infection with different clinical presentations, severity, and prevalence. The most critical ones, such as cerebrovascular disease, encephalopathy, and Guillain-Barre syndrome, were less common and usually associated with previous medical history, known risk factors for cerebrovascular disease or advanced age. The main hypotheses for the spread of the virus are through the hematogenous route or the cribriform plate of the ethmoid bone or a disseminated severe immune response by a cytokine storm. The presence of neurological disturbances associated with laboratory tests alterations is an important clue for the physicians to promptly recognize neurological manifestations of SARS-CoV-2.

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