绵羊(Ovis aries)心肌梗死诱导后伴有左心室损伤的炎症反应。

IF 1.3 4区 农林科学 Q2 VETERINARY SCIENCES
Comparative medicine Pub Date : 2021-06-01 Epub Date: 2021-06-03 DOI:10.30802/AALAS-CM-21-000005
Hylton P Gordon, Michael G Katz, Shahood Fazal, Virginia L Gillespie, Anthony S Fargnoli, Sarah M Gubara, Sophia J Madjarova, Jonathan A Cohen
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引用次数: 0

摘要

缺血性心肌疾病是全世界人类死亡的一个主要原因;它导致心肌的疤痕和苍白,并引发炎症反应,导致左心室功能受损。这种反应包括多种炎症细胞因子的产生,包括TNFα、IL1β、IL4、IFNγ、IL10和IL6。在本研究中,通过结扎左旋钝缘动脉(om1和om2)诱导6月龄雄性阉割绵羊心肌梗死。MRI测量左心室功能参数,包括基线、诱导梗死后4周和3个月的EDV、ESV、EF、SVI、dp/dt max和dp/dt min。我们还测量了一系列细胞因子的血清浓度。死后组织学结果证实存在左心室心肌损伤和恶化。我们的数据显示血清细胞因子浓度与心肌损伤和左心室功能损害的发展之间存在相关性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Inflammatory Responses with Left Ventricular Compromise after Induction of Myocardial Infarcts in Sheep (Ovis aries).

Ischemic myocardial disease is a major cause of death among humans worldwide; it results in scarring and pallor of the myocardium and triggers an inflammatory response that contributes to impaired left ventricular function. This response includes and is evidenced by the production of several inflammatory cytokines including TNFα, IL1β, IL4, IFNγ, IL10 and IL6. In the current study, myocardial infarcts were induced in 6 mo old male castrated sheep by ligation of the left circumflex obtuse marginal arteries (OM 1 and 2). MRI was used to measure parameters of left ventricular function that include EDV, ESV, EF, SVI, dp/dt max and dp/dt min at baseline and at 4 wk and 3 mo after infarct induction. We also measured serum concentrations of an array of cytokines. Postmortem histologic findings corroborate the existence of left ventricular myocardial injury and deterioration. Our data show a correlation between serum cytokine concentrations and the development of myocardial damage and left ventricular functional compromise.

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来源期刊
Comparative medicine
Comparative medicine 医学-动物学
CiteScore
1.90
自引率
0.00%
发文量
71
审稿时长
6-12 weeks
期刊介绍: Comparative Medicine (CM), an international journal of comparative and experimental medicine, is the leading English-language publication in the field and is ranked by the Science Citation Index in the upper third of all scientific journals. The mission of CM is to disseminate high-quality, peer-reviewed information that expands biomedical knowledge and promotes human and animal health through the study of laboratory animal disease, animal models of disease, and basic biologic mechanisms related to disease in people and animals.
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