180例腹膜癌减胞术及围手术期腹腔内化疗的经验分析。

IF 1.6 Q4 ONCOLOGY
International Journal of Surgical Oncology Pub Date : 2021-04-22 eCollection Date: 2021-01-01 DOI:10.1155/2021/8851751
Kursat Karadayi, Meric Emre Bostanci, Murat Can Mollaoglu, Ufuk Karabacak
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引用次数: 6

摘要

背景:在腹膜癌(PC)中,在细胞减少手术(SRC)后进行高温腹腔化疗(HIPEC)和术后早期腹腔化疗(EPIC)的患者的寿命和无病生存时间增加。在这项研究中,我们的主要目的是根据文献介绍我们对PC患者进行SRC和围手术期腹腔内化疗(HIPEC和EPIC)的经验。方法:回顾性分析2008年1月至2020年7月在西vas Cumhuriyet大学外科肿瘤科接受SRC + HIPEC + EPIC治疗的180例PC患者的人口统计学资料、随访结果、腹膜癌指数(PCI)、细胞减少完整性(CCR)评分、发病率和死亡率。结果:180例PC按原发器官分布:卵巢53例,结直肠39例,胃33例,腹膜25例,子宫10例,气管10例,软组织5例,阑尾5例。术前发现患者PCI平均为21次(5 ~ 30次)。获得102例CCR-0、67例CCR-1、8例CCR-2、3例CCR-3细胞减少评分的完全性。中位手术时间300(200-540)分钟。围手术期发病率47.0%,死亡率13.5%。结论:腹膜切除术是一项困难、持久、麻烦的干预措施,但在经验丰富的中心,它是选择PC治疗的患者中发病率和死亡率可接受的最重要的治疗方案。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Cytoreductive Surgery and Perioperative Intraperitoneal Chemotherapy Experience in Peritoneal Carcinomatosis: Single-Center Analysis of 180 Cases.

Cytoreductive Surgery and Perioperative Intraperitoneal Chemotherapy Experience in Peritoneal Carcinomatosis: Single-Center Analysis of 180 Cases.

Cytoreductive Surgery and Perioperative Intraperitoneal Chemotherapy Experience in Peritoneal Carcinomatosis: Single-Center Analysis of 180 Cases.

Cytoreductive Surgery and Perioperative Intraperitoneal Chemotherapy Experience in Peritoneal Carcinomatosis: Single-Center Analysis of 180 Cases.

Background: In peritoneal carcinomatosis (PC), increased life span and disease-free survival times are shown in patients with hyperthermic intraperitoneal chemotherapy (HIPEC) and early postoperative intraperitoneal chemotherapy (EPIC) following cytoreductive surgery (SRC). In this study, our main objective was to present our experience of performing SRC and perioperative intraperitoneal chemotherapy (HIPEC and EPIC) on patients with PC, in light of the literature.

Methods: Demographic data, follow-up results, peritoneal carcinomatosis index (PCI), completeness of cytoreduction (CCR) score, and morbidity and mortality rates of 180 patients treated with SRC + HIPEC + EPIC for PC at the Department of Surgical Oncology at Sivas Cumhuriyet University between January 2008 and July 2020 were analyzed retrospectively.

Results: Distribution of 180 PC cases according to primary organs included 53 ovarian, 39 colorectal, 33 stomach, 25 primary peritoneum, 10 uterus, 10 tuba, five soft tissue, and five appendix originated carcinoma. The average PCI of the cases detected preoperatively was 21 (5-30). Completeness of cytoreduction scores of CCR-0 in 102 cases, CCR-1 in 67 cases, CCR-2 in eight cases, and CCR-3 in three cases was obtained. Median operation time was 300 (200-540) minutes. Perioperative morbidity rate was 47.0%, and perioperative mortality rate was 13.5%.

Conclusion: The peritonectomy procedure is a difficult, long-lasting, troublesome intervention, but it is the most important treatment option with acceptable morbidity and mortality rates in patients selected for PC treatment in experienced centers.

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来源期刊
CiteScore
3.70
自引率
0.00%
发文量
5
审稿时长
20 weeks
期刊介绍: International Journal of Surgical Oncology is a peer-reviewed, Open Access journal that publishes original research articles, review articles, and clinical studies in all areas of surgical oncology.
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