分析胶质瘤微环境的啮齿动物模型

IF 3.9 4区医学 Q2 NEUROSCIENCES

ASN NEURO Pub Date : 2021-01-01 DOI:10.1177/17590914211005074

Susann Hetze, Ulrich Sure, Manfred Schedlowski, Martin Hadamitzky, Lennart Barthel

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引用次数: 0

摘要

要了解胶质瘤发展和侵袭的基本原理，动物模型仍然不可或缺。临床前方法旨在分析新药的治疗效果，然后再将其转化为临床试验。目前有多种动物疾病模型，但并非每种方法都能解决特定问题。近年来，肿瘤微环境对胶质瘤性质的关键作用日益明显。本综述除了提供概述外，还从胶质瘤微环境研究的可用性方面对现有的啮齿类动物模型进行了评估。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Rodent Models to Analyze the Glioma Microenvironment.

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Rodent Models to Analyze the Glioma Microenvironment.

Animal models are still indispensable for understanding the basic principles of glioma development and invasion. Preclinical approaches aim to analyze the treatment efficacy of new drugs before translation into clinical trials is possible. Various animal disease models are available, but not every approach is useful for addressing specific questions. In recent years, it has become increasingly evident that the tumor microenvironment plays a key role in the nature of glioma. In addition to providing an overview, this review evaluates available rodent models in terms of usability for research on the glioma microenvironment.

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来源期刊

ASN NEURO NEUROSCIENCES-

CiteScore

7.70

自引率

4.30%

发文量

审稿时长

>12 weeks

期刊介绍： ASN NEURO is an open access, peer-reviewed journal uniquely positioned to provide investigators with the most recent advances across the breadth of the cellular and molecular neurosciences. The official journal of the American Society for Neurochemistry, ASN NEURO is dedicated to the promotion, support, and facilitation of communication among cellular and molecular neuroscientists of all specializations.