白细胞介素-1β和尿酸作为子痫前期妊娠中期潜在的预测性生物标志物

IF 1.5 4区医学 Q3 OBSTETRICS & GYNECOLOGY

Hypertension in Pregnancy Pub Date : 2021-08-01 Epub Date: 2021-05-06 DOI:10.1080/10641955.2021.1921793

Keziban Dogan, Alev Kural, Yasin Oztoprak, Murat Dogan

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引用次数: 2

摘要

方法:前瞻性研究于2020年2月至2020年12月在大学医院进行。研究人群(n = 88)包括后来发生PE的妇女(n = 42)，以及在妊娠中期出生时健康的妇女(n = 46)。比较各组血清CRP、IL-1β、尿酸、肌酐、AST、ALT、MPV、Hb、PC、维生素D、Ca、Mg水平。结果:最终发生PE的受试者血清IL-1β和尿酸水平明显高于未发生PE的受试者。结论:IL-1β和尿酸可能是PE的预测指标。妊娠中期孕妇血清IL-1β和尿酸水平可能是PE的预测指标。

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Interleukin-1β and uric acid as potential second-trimester predictive biomarkers of preeclampsia.

ABSTRACT Methods: The prospective study was conducted at the University Hospital from February 2020 to December 2020. The study population (n = 88) included women who later developed PE (n = 42), as well as women who were healthy at birth (n = 46) in the second trimester of pregnancy. Serum levels of CRP, IL-1β, uric acid, creatinine, AST, ALT, MPV, Hb, PC, vitamin D, Ca, and Mg were compared between the groups. Results: Serum IL-1β and uric acid levels were significantly higher in subjects who eventually developed PE compared with those who did not. Conclusions: IL-1β and uric acid may be a predictive markers for PE. Maternal serum IL-1β and uric acid levels in the second trimester of pregnancy may be a predictive markers for PE.

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来源期刊

Hypertension in Pregnancy 医学-妇产科学

CiteScore

3.40

自引率

0.00%

发文量

审稿时长

6 months

期刊介绍： Hypertension in Pregnancy is a refereed journal in the English language which publishes data pertaining to human and animal hypertension during gestation. Contributions concerning physiology of circulatory control, pathophysiology, methodology, therapy or any other material relevant to the relationship between elevated blood pressure and pregnancy are acceptable. Published material includes original articles, clinical trials, solicited and unsolicited reviews, editorials, letters, and other material deemed pertinent by the editors.