纠正eGFR对ART对小管肌酐分泌的影响:一种方法适合所有人吗?

IF 2.3 4区医学 Q4 INFECTIOUS DISEASES

Antiviral Therapy Pub Date : 2020-01-01 DOI:10.3851/IMP3378

Frank A Post, Lisa Hamzah

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引用次数: 2

摘要

包括多替格拉韦、利匹韦林和可比司他在内的几种抗逆转录病毒药物抑制小管肌酐分泌，导致血清肌酐良性升高和估计肾小球滤过率(eGFR)降低。这篇评论讨论了eGFR下降的幅度和模式，是否可以通过应用标准化校正因子(如Brunet等人在抗病毒治疗中报道的)来克服这一问题，系列eGFR测量检测eGFR快速下降的价值，以及胱抑素C作为肾功能替代生物标志物的潜在效用。

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Correcting eGFR for the effects of ART on tubular creatinine secretion: does one size fit all?

Several antiretrovirals including dolutegravir, rilpivirine and cobicistat inhibit tubular creatinine secretion, leading to benign increases in serum creatinine and reductions in estimated glomerular filtration rate (eGFR). This commentary discusses the magnitude and pattern of eGFR decline, whether this can be overcome by applying a standardized correction factor (as reported by Brunet et al. in Antiviral Therapy), the value of serial eGFR measures to detect rapid eGFR decline and the potential utility of cystatin C as an alternative biomarker of kidney function.

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来源期刊

Antiviral Therapy 医学-病毒学

CiteScore

2.60

自引率

8.30%

发文量

审稿时长

4-8 weeks

期刊介绍： Antiviral Therapy (an official publication of the International Society of Antiviral Research) is an international, peer-reviewed journal devoted to publishing articles on the clinical development and use of antiviral agents and vaccines, and the treatment of all viral diseases. Antiviral Therapy is one of the leading journals in virology and infectious diseases. The journal is comprehensive, and publishes articles concerning all clinical aspects of antiviral therapy. It features editorials, original research papers, specially commissioned review articles, letters and book reviews. The journal is aimed at physicians and specialists interested in clinical and basic research.