母体营养和氧化应激在子痫前期妇女胎盘端粒磨损中的作用。

IF 1.5 4区医学 Q3 OBSTETRICS & GYNECOLOGY

Hypertension in Pregnancy Pub Date : 2021-02-01 Epub Date: 2021-01-07 DOI:10.1080/10641955.2020.1869248

Aditi A Godhamgaonkar, Deepali P Sundrani, Sadhana R Joshi

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引用次数: 4

摘要

背景:母体营养影响胎儿的生长发育，影响妊娠结局。我们早前已经证明孕妇营养改变和氧化应激增加的先兆子痫妇女。氧化应激已知与端粒长度减少和端粒聚集物缩短有关。端粒磨损增加导致细胞衰老和组织老化增加。方法:本文综述了母体营养和氧化应激在子痫前期端粒磨损中的作用。结果和结论:未来的研究需要检查妊娠早期产妇营养状况、氧化应激和子痫前期端粒磨损之间的关系。

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Role of maternal nutrition and oxidative stress in placental telomere attrition in women with preeclampsia.

Background:Maternal nutrition influences the growth and development of the fetus and influences pregnancy outcome. We have earlier demonstrated altered maternal nutrition and increased oxidative stress in women with preeclampsia. Oxidative stress is known to be associated with reduced telomere length and short telomere aggregates. Increased telomere attrition leads to increased cellular senescence and tissue ageing. Methods:The present review focuses on the role of maternal nutrition and oxidative stress in telomere attrition in preeclampsia. Results and Conclusion:Future studies need to examine the association between maternal nutritional status in early pregnancy, oxidative stress and telomere attrition in preeclampsia.

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来源期刊

Hypertension in Pregnancy 医学-妇产科学

CiteScore

3.40

自引率

0.00%

发文量

审稿时长

6 months

期刊介绍： Hypertension in Pregnancy is a refereed journal in the English language which publishes data pertaining to human and animal hypertension during gestation. Contributions concerning physiology of circulatory control, pathophysiology, methodology, therapy or any other material relevant to the relationship between elevated blood pressure and pregnancy are acceptable. Published material includes original articles, clinical trials, solicited and unsolicited reviews, editorials, letters, and other material deemed pertinent by the editors.