hiv感染者感染性心内膜炎的病程和临床结果:一项系统综述和荟萃分析。

IF 1.9 4区 医学 Q4 IMMUNOLOGY
Joris Bos, Christiaan F J Antonides, Roos E Barth, Kerstin Klipstein-Grobusch, Ruchika Meel, Alinda G Vos
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引用次数: 0

摘要

感染性心内膜炎(IE)如果不治疗,会导致大量的发病率和死亡率。由于免疫功能障碍,hiv阳性患者的IE临床病程可能不同。本系统综述调查了hiv阳性和hiv阴性患者IE的临床病程。在PubMed、EMBASE和Cochrane Library中进行系统检索,并在PROSPERO中注册(CRD42016048649)。从1996年及以后的所有关于hiv阳性成人IE临床结果的文章被回顾,并根据预先确定的纳入和排除标准纳入。对结果死亡率进行荟萃分析。纳入了23篇文章,其中8篇仅包括艾滋病毒阳性患者,15篇比较了艾滋病毒阳性和艾滋病毒阴性患者。两项研究包括接受抗逆转录病毒治疗(ART)的患者。HIV与静脉吸毒(IVDU)密切相关。CD4细胞计数低于200细胞/μl的hiv阳性患者死亡率高于CD4细胞计数较高的hiv阳性患者,而hiv阳性患者死亡率与hiv阴性患者相似(风险比= 0.86[95%置信区间:0.53-1.40])。住院时间和再住院时间没有差异。临床结果与右侧或左侧心内膜炎密切相关。HIV感染者和非HIV感染者的IE临床病程无明显差异。临床结果主要与其他因素相关,如IVDU和心脏受累侧,而不是HIV状态。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Course of Disease and Clinical Outcome of Infective Endocarditis in HIV-infected Individuals: A Systematic Review and Meta-analysis.

Infective endocarditis (IE) causes substantial morbidity and mortality if untreated. The clinical course of IE might be different in HIV-positive patients as a result of immune dysfunction. This systematic review investigates the clinical course of IE in HIV-positive compared to HIV-negative patients. A systematic search was performed in PubMed, EMBASE, and Cochrane Library and registered in PROSPERO (CRD42016048649). All articles from 1996 and onward addressing the clinical outcome of HIV-positive adults suffering from IE were reviewed and included based on predefined inclusion and exclusion criteria. A meta-analysis was performed for the outcome mortality. Twenty-three articles were included of which eight included HIVpositive patients only, and 15 compared HIV-positive to HIV-negative patients. Two studies included patients on antiretroviral therapy (ART). HIV and intravenous drug use (IVDU) were closely related. Mortality was higher in HIV-positive patients with a CD4 count below 200 cells/μl than in HIV-positive patients with a higher CD4 count, while mortality was similar for HIV-positive compared to HIV-negative patients (risk ratio = 0.86 [95% confidence interval: 0.53-1.40]). No difference was found in length of hospital stay or rehospitalization. Clinical outcomes were strongly related to the right- or left-sided endocarditis. The clinical course of IE is not different for patients with and without HIV. Clinical outcomes were mainly associated with other factors, such as IVDU and side of cardiac involvement, rather than HIV status.

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来源期刊
AIDS reviews
AIDS reviews 医学-传染病学
CiteScore
3.40
自引率
4.50%
发文量
41
审稿时长
>12 weeks
期刊介绍: AIDS Reviews publishes papers reporting original scientific, clinical, epidemiologic and social research which contribute to the overall knowledge of the field of the acquired immunodeficiency syndrome and human retrovirology. Currently, the Journal publishes review articles (usually by invitation, but spontaneous submitted articles will also be considered). Manuscripts submitted to AIDS Reviews will be accepted on the understanding that the authors have not submitted the paper to another journal or published the material elsewhere.
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