基于共加工赋形剂的最新专利和专利技术平台综述。

Deepak Kaushik, Etisha Goel, Ravinder Verma, Parijat Pandey, Deepika Purohit, Vineet Mittal, Kuldeep Kumar, Md Habibur Rahman
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引用次数: 2

摘要

背景:没有一种单组分赋形剂能够满足所有必需的性能,使活性药物成分能够被配制成特定的剂型。协同加工是一个新概念,包含两种或两种以上赋形剂的组合,这是有利的,不能使用物理混合物来实现。目的:综述共加工辅料、该领域近期授权和申请的专利以及基于这些辅料的商业化专利技术平台。方法:利用各种在线专利数据库,收集最新专利和共加工辅料技术专利信息。介绍了干包衣单步共加工、新型油类药物共加工赋形剂和新型二氧化硅包覆组合物等最新专利。结果:协同加工辅料是当前和未来制药辅料技术的发展趋势,这一点从基于这些辅料的专利数量的增加可以看出。在各种技术中,专利数量最多的是喷雾干燥技术。结论:本文对近年来共加工赋形剂的专利和商业技术进行了综述。更好地了解这一点将有助于研究人员和制药行业选择合适的平台,或开发具有改进片剂特性的新的创新共加工辅料。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
An Overview of Recent Patents and Patented Technology Platforms Based on Co-Processed Excipients.

Background: There is no single-component excipient that fulfills all the requisite performance to allow an active pharmaceutical ingredient to be formulated into a specific dosage form. Co-processing is a novel concept that incorporates a combination of two or more excipients, that is advantageous and cannot be achieved using a physical admixture.

Objective: This review provides an overview of co-processed excipients, recent patents granted and filed in this field and the commercial patented technology platforms based on these excipients.

Methods: Various online patent databases were used for collecting the information on recent patents and patented co-processed excipient technologies. The recent patents such as single-step coprocessing by dry coating, novel co-processed excipients for oily drugs and novel silica-coated compositions have been discussed.

Results: Co-processed excipients are evolving as a current and future trend of excipient technology in pharmaceutical manufacturing, which is evident by the increasing number of patents based on these excipients. Among various techniques, the maximum number of patents is based on the spray drying technique.

Conclusion: In this work, the authors have focussed on recent patents and commercial technologies on co-processed excipient. A better understanding of this will help researchers and pharmaceutical industries to select the appropriate platform, or to develop new innovative co-processed excipients with improved tableting characteristics.

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