膀胱尿路上皮癌三级淋巴结构的当前概念:文献回顾和我们的经验。

IF 1.4 Q4 IMMUNOLOGY
American journal of clinical and experimental immunology Pub Date : 2020-12-15 eCollection Date: 2020-01-01
Milena Gulinac, Dorian Dikov, Simeon Lichev, Tsvetelina Velikova
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引用次数: 0

摘要

膀胱癌(BC)是发达国家泌尿系统最常见的恶性肿瘤之一,具有很高的复发率。次级淋巴器官(SLO)是启动适应性免疫反应的关键。它们是胚胎发育过程中基因预编程过程的一部分。然而,SLO的器官发生可以在其他组织中通过称为淋巴样新发生的过程重新复制,产生三级淋巴样结构(TLS)。肿瘤中这些组织良好的淋巴样结构是肿瘤免疫反应的重要调节因子,对TLS的组织学检查为肿瘤免疫治疗提供了新的策略。本文综述了肌肉非侵袭性和侵袭性BC中TLS的生物学和组织学特征。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Current concept for tertiary lymphoid structures in urothelial carcinoma of the bladder: a literature review and our experience.

Bladder carcinoma (BC) is one of the most common malignancies of the urinary system in developed countries, with a high number of recurrences. The secondary lymphoid organs (SLO) are crucial for initiating the adaptive immune response. They are developed as a part of a genetically preprogrammed process during embryogenesis. However, SLO's organogenesis can be reduplicated de novo in other tissues by a process termed lymphoid neo-genesis, giving rise to tertiary lymphoid structures (TLS). These well-organized lymphoid structures in cancer are essential modulators of cancer immunologic response, and the histological examination of TLS gave a new strategy for cancer immunotherapy. This review explores the biological and histological characteristics of TLS in muscle non-invasive and invasive BC.

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