作为主动适应材料的肌动蛋白细胞骨架

IF 14.3 1区 物理与天体物理 Q1 PHYSICS, CONDENSED MATTER
Shiladitya Banerjee, Margaret L Gardel, Ulrich S Schwarz
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引用次数: 0

摘要

肌动蛋白是生物细胞用来使其结构和力学适应需要的主要蛋白质。细胞的适应是通过分子过程实现的,而分子过程在很大程度上依赖于力学。肌动蛋白细胞骨架也是一种持续消耗能量的活性材料。在这里,我们将从物理学的角度讨论肌动蛋白细胞骨架,它是一种主动适应材料,可以构建优于人造软物质系统的结构。肌动蛋白不仅可以按需以自适应的方式构建不同的网络结构,而且还表现出反馈系统的动态特性,如兴奋性、双稳态性或振荡。因此,它是生物学如何将物理结构与信息流结合起来的一个典型例子,也是受生物学启发的超材料的典范。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The Actin Cytoskeleton as an Active Adaptive Material.

Actin is the main protein used by biological cells to adapt their structure and mechanics to their needs. Cellular adaptation is made possible by molecular processes that strongly depend on mechanics. The actin cytoskeleton is also an active material that continuously consumes energy. This allows for dynamical processes that are possible only out of equilibrium and opens up the possibility for multiple layers of control that have evolved around this single protein.Here we discuss the actin cytoskeleton from the viewpoint of physics as an active adaptive material that can build structures superior to man-made soft matter systems. Not only can actin be used to build different network architectures on demand and in an adaptive manner, but it also exhibits the dynamical properties of feedback systems, like excitability, bistability, or oscillations. Therefore, it is a prime example of how biology couples physical structure and information flow and a role model for biology-inspired metamaterials.

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来源期刊
Annual Review of Condensed Matter Physics
Annual Review of Condensed Matter Physics PHYSICS, CONDENSED MATTER-
CiteScore
47.40
自引率
0.90%
发文量
27
期刊介绍: Since its inception in 2010, the Annual Review of Condensed Matter Physics has been chronicling significant advancements in the field and its related subjects. By highlighting recent developments and offering critical evaluations, the journal actively contributes to the ongoing discourse in condensed matter physics. The latest volume of the journal has transitioned from gated access to open access, facilitated by Annual Reviews' Subscribe to Open initiative. Under this program, all articles are now published under a CC BY license, ensuring broader accessibility and dissemination of knowledge.
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