前列腺癌与治疗挑战。

IF 1.9 3区生物学 Q2 BIOLOGY

Journal of Biological Research-Thessaloniki Pub Date : 2020-12-10 DOI:10.1186/s40709-020-00128-z

Yousef MohammedRabaa Hawsawi, Samar Abdullah Zailaie, Atif Abdulwahab A Oyouni, Othman Rashed Alzahrani, Osama Mohamed Alamer, Saad Ali S Aljohani

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引用次数: 0

摘要

前列腺癌（PC）是全球男性最常见的癌症类型。在沙特阿拉伯，前列腺癌的发病率呈逐年上升趋势。性类固醇激素和雄激素及其受体在前列腺癌的发生和发展过程中起着至关重要的作用。此外，与细胞凋亡相关的蛋白（如热休克蛋白）也是 PC 发病过程中的重要分子。类固醇激素剥夺疗法仍然是转移性 PC 患者的基本治疗方法；然而，获得性对激素剥夺的耐药性以及向 PC 雄性激素独立性的过渡是一个主要的健康障碍。在这篇综述中，我们将详细介绍雄激素、雄激素受体和性类固醇激素在诱导 PC 细胞凋亡中的作用。

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Prostate cancer and therapeutic challenges.

Prostate cancer (PC) is the most prevalent type of cancer in men worldwide. In Saudi Arabia, the rate of PC is increasing annually. The sex steroid hormones androgens and their receptors have critical roles in PC development and progression. Additionally, apoptosis-related proteins such as heat-shock proteins are vital molecules in PC development. Steroid hormone-deprivation therapies remain the essential treatment for patients with metastatic PCs; however, acquired resistance to hormone deprivation and the transition to PC androgen independence is a major health obstacle. In this review, we aim to detail the roles of androgens, androgen receptors and sex steroid hormones in inducing apoptosis in PC.

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来源期刊

Journal of Biological Research-Thessaloniki 生物-生物学

CiteScore

5.20

自引率

0.00%

发文量

审稿时长

>12 weeks

期刊介绍： Journal of Biological Research-Thessaloniki is a peer-reviewed, open access, international journal that publishes articles providing novel insights into the major fields of biology. Topics covered in Journal of Biological Research-Thessaloniki include, but are not limited to: molecular biology, cytology, genetics, evolutionary biology, morphology, development and differentiation, taxonomy, bioinformatics, physiology, marine biology, behaviour, ecology and conservation.