对肠道菌群进行 Virechana Karma(治疗性净化)的临床研究,特别是肥胖症。

Ayu Pub Date : 2019-07-01 Epub Date: 2020-08-08 DOI:10.4103/ayu.AYU_302_19
Ashutosh Chaturvedi, Gopal Nath, Virender Bhadur Yadav, Meera Antiwal, Niharika Shakya, C Swathi, Jai Prakash Singh
{"title":"对肠道菌群进行 Virechana Karma(治疗性净化)的临床研究,特别是肥胖症。","authors":"Ashutosh Chaturvedi, Gopal Nath, Virender Bhadur Yadav, Meera Antiwal, Niharika Shakya, C Swathi, Jai Prakash Singh","doi":"10.4103/ayu.AYU_302_19","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Altered gut flora is associated with the pathogenesis of both intestinal and extra‑intestinal disorders. Aetiology of obesity is associated with mechanisms such as short chain fatty acid production, stimulation of hormones, chronic low‑grade inflammation, lipoprotein and bile acid metabolism and increased endocannabinoid. Receptor system tone have been suggested to explain the role of gut microbiota of obesity. The <i>Panchakarma</i> (Ayurvedic purification methods) claims the management of metabolic disorders hence this work provides the target specific evidence for the clinical studies. The proposed project is aimed to explore the particular molecular mechanism and, to make this therapy more evidence based. Hence, it was hypothesized that <i>Panchakarma</i>‑based intervention such as <i>Virechana Karma</i> (therapeutic purgation) may influence microbiota and help in the management of the obesity.</p><p><strong>Materials and methods: </strong>The study was conducted to explore the effect of <i>Virechana</i> <i>Karma</i> over the gut flora; therefore, total of 19 patients with <i>Madhyama</i> <i>Koshtha</i> diagnosed with obesity were included and received the intervention. Before and after <i>Virechana</i>, a stool sample was collected and processed for the enterobacterial repetitive intergenic consensus ‑polymerase chain reaction to find the changes over the facultative aerobic bacteria.</p><p><strong>Results: </strong>It was found that <i>Virechana</i> is effective in the management of the obesity as it helps to reduce colonization of aerobic bacteria. After <i>Virechana</i> and after follow‑up also, it showed the correction of the gut flora dysbiosis, thus initiated the weight loss mechanism in the body, resulting in diminution in the signs and symptoms of obesity.</p><p><strong>Conclusion: </strong><i>Virechana</i> is effective in the management of the obesity due to reduction in the <i>Escherichia coli</i> colonization and is effective over the gut flora dysbiosis.</p>","PeriodicalId":8720,"journal":{"name":"Ayu","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2019-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/db/dd/AYU-40-179.PMC7685265.pdf","citationCount":"0","resultStr":"{\"title\":\"A clinical study on <i>Virechana Karma</i> (therapeutic purgation) over the gut flora with special reference to obesity.\",\"authors\":\"Ashutosh Chaturvedi, Gopal Nath, Virender Bhadur Yadav, Meera Antiwal, Niharika Shakya, C Swathi, Jai Prakash Singh\",\"doi\":\"10.4103/ayu.AYU_302_19\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Altered gut flora is associated with the pathogenesis of both intestinal and extra‑intestinal disorders. Aetiology of obesity is associated with mechanisms such as short chain fatty acid production, stimulation of hormones, chronic low‑grade inflammation, lipoprotein and bile acid metabolism and increased endocannabinoid. Receptor system tone have been suggested to explain the role of gut microbiota of obesity. The <i>Panchakarma</i> (Ayurvedic purification methods) claims the management of metabolic disorders hence this work provides the target specific evidence for the clinical studies. The proposed project is aimed to explore the particular molecular mechanism and, to make this therapy more evidence based. Hence, it was hypothesized that <i>Panchakarma</i>‑based intervention such as <i>Virechana Karma</i> (therapeutic purgation) may influence microbiota and help in the management of the obesity.</p><p><strong>Materials and methods: </strong>The study was conducted to explore the effect of <i>Virechana</i> <i>Karma</i> over the gut flora; therefore, total of 19 patients with <i>Madhyama</i> <i>Koshtha</i> diagnosed with obesity were included and received the intervention. Before and after <i>Virechana</i>, a stool sample was collected and processed for the enterobacterial repetitive intergenic consensus ‑polymerase chain reaction to find the changes over the facultative aerobic bacteria.</p><p><strong>Results: </strong>It was found that <i>Virechana</i> is effective in the management of the obesity as it helps to reduce colonization of aerobic bacteria. After <i>Virechana</i> and after follow‑up also, it showed the correction of the gut flora dysbiosis, thus initiated the weight loss mechanism in the body, resulting in diminution in the signs and symptoms of obesity.</p><p><strong>Conclusion: </strong><i>Virechana</i> is effective in the management of the obesity due to reduction in the <i>Escherichia coli</i> colonization and is effective over the gut flora dysbiosis.</p>\",\"PeriodicalId\":8720,\"journal\":{\"name\":\"Ayu\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2019-07-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/db/dd/AYU-40-179.PMC7685265.pdf\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Ayu\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.4103/ayu.AYU_302_19\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2020/8/8 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Ayu","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.4103/ayu.AYU_302_19","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2020/8/8 0:00:00","PubModel":"Epub","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0

摘要

背景:肠道菌群的改变与肠道和肠道外疾病的发病机制有关。肥胖症的病因与短链脂肪酸生成、激素刺激、慢性低度炎症、脂蛋白和胆汁酸代谢以及内源性大麻素增加等机制有关。有人认为,受体系统的调节作用可以解释肠道微生物群在肥胖症中的作用。Panchakarma(阿育吠陀净化方法)声称可以治疗代谢紊乱,因此这项工作为临床研究提供了目标明确的证据。拟议的项目旨在探索特定的分子机制,使这种疗法更有依据。因此,我们假设以潘查卡玛疗法(Panchakarma)为基础的干预措施,如 Virechana Karma(治疗性净化),可能会影响微生物群,并有助于肥胖症的治疗:本研究旨在探讨 Virechana Karma 对肠道菌群的影响,因此共纳入了 19 名被诊断为肥胖症的 Madhyama Koshtha 患者,他们都接受了干预。在接受 Virechana 之前和之后,采集粪便样本并进行肠道细菌重复基因间共识聚合酶链反应,以发现兼性需氧菌的变化:结果:研究发现,Virechana 能有效控制肥胖症,因为它有助于减少需氧菌的定植。经过 Virechana 和后续治疗后,肠道菌群失调得到了纠正,从而启动了体内减肥机制,减少了肥胖的症状和体征:结论:Virechana 能有效控制肥胖症,因为它能减少大肠埃希氏菌的定植,并对肠道菌群失调有效。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

A clinical study on <i>Virechana Karma</i> (therapeutic purgation) over the gut flora with special reference to obesity.

A clinical study on Virechana Karma (therapeutic purgation) over the gut flora with special reference to obesity.

Background: Altered gut flora is associated with the pathogenesis of both intestinal and extra‑intestinal disorders. Aetiology of obesity is associated with mechanisms such as short chain fatty acid production, stimulation of hormones, chronic low‑grade inflammation, lipoprotein and bile acid metabolism and increased endocannabinoid. Receptor system tone have been suggested to explain the role of gut microbiota of obesity. The Panchakarma (Ayurvedic purification methods) claims the management of metabolic disorders hence this work provides the target specific evidence for the clinical studies. The proposed project is aimed to explore the particular molecular mechanism and, to make this therapy more evidence based. Hence, it was hypothesized that Panchakarma‑based intervention such as Virechana Karma (therapeutic purgation) may influence microbiota and help in the management of the obesity.

Materials and methods: The study was conducted to explore the effect of Virechana Karma over the gut flora; therefore, total of 19 patients with Madhyama Koshtha diagnosed with obesity were included and received the intervention. Before and after Virechana, a stool sample was collected and processed for the enterobacterial repetitive intergenic consensus ‑polymerase chain reaction to find the changes over the facultative aerobic bacteria.

Results: It was found that Virechana is effective in the management of the obesity as it helps to reduce colonization of aerobic bacteria. After Virechana and after follow‑up also, it showed the correction of the gut flora dysbiosis, thus initiated the weight loss mechanism in the body, resulting in diminution in the signs and symptoms of obesity.

Conclusion: Virechana is effective in the management of the obesity due to reduction in the Escherichia coli colonization and is effective over the gut flora dysbiosis.

求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
Ayu
Ayu
自引率
0.00%
发文量
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信