在一个充满碘的地区超重和肥胖个体中确定年龄和性别特异性TSH和FT4参考限值:德黑兰甲状腺研究(TTS)

IF 1.5 4区 医学 Q4 ENDOCRINOLOGY & METABOLISM
Endocrine Research Pub Date : 2021-02-01 Epub Date: 2020-12-07 DOI:10.1080/07435800.2020.1854778
Hengameh Abdi, Bita Faam, Safoora Gharibzadeh, Ladan Mehran, Maryam Tohidi, Fereidoun Azizi, Atieh Amouzegar
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引用次数: 3

摘要

根据体重指数(BMI)分类确定年龄和性别特异性促甲状腺激素(TSH)和游离甲状腺素(FT4)参考范围。方法:根据美国国家临床生物化学研究院(NACB)的标准,从德黑兰甲状腺研究人群中选择2818名个体,将其分为三个BMI组。结果:TSH水平在BMI组间无显著差异(p = 0.054)。在所有BMI类别中,女性的TSH水平在统计学上都高于男性(TSH的百分位数大致保持不变,而97.5%的百分位数呈上升趋势。与肥胖个体相比,正常体重组FT4水平显著升高(FT4的第1百分位和第975百分位随BMI升高而升高)。结论:与正常体重人群相比,肥胖个体FT4浓度略低,TSH水平相似。随着BMI的增加,TSH上限和FT4上限分别呈上升和下降趋势。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Determination of age and sex specific TSH and FT4 reference limits in overweight and obese individuals in an iodine-replete region: Tehran Thyroid Study (TTS).

Introduction: To determine age and sex-specific thyrotropin (TSH) and free thyroxine (FT4) reference ranges according to body mass index (BMI) categories. Methods: With regards to the National Academy of Clinical Biochemistry (NACB) criteria, a total of 2818 individuals from the Tehran Thyroid Study population was selected and categorized in three BMI groups. Results: TSH levels did not differ significantly between BMI groups (p = .054). Females had statistically higher TSH levels than males in all BMI categories (p < .001). According to age-specific analyses, the youngest category (20-29 years) had the highest median values of serum TSH in all BMI groups. With increasing BMI, the 2.5th percentile of TSH remained approximately unchanged and the 97.5th percentile showed an increasing pattern. FT4 level was significantly higher in the normal weight group compared to obese individuals (p < .001); females had significantly lower FT4 levels than males in normal weight and obese groups (p < .001). According to age categories, the youngest group (20-29 years) had higher levels of FT4 than the elderly group in all BMI categories. A decreasing pattern in both 2.5th and 97.5th percentiles of FT4 was observed along with increasing BMI. Conclusions: Compared to the normal weight population, obese individuals have slightly lower FT4 concentrations accompanied by similar TSH levels. With increasing BMI, upper limits of TSH and FT4 show increasing and decreasing patterns, respectively.

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来源期刊
Endocrine Research
Endocrine Research 医学-内分泌学与代谢
CiteScore
4.30
自引率
0.00%
发文量
10
审稿时长
>12 weeks
期刊介绍: This journal publishes original articles relating to endocrinology in the broadest context. Subjects of interest include: receptors and mechanism of action of hormones, methodological advances in the detection and measurement of hormones; structure and chemical properties of hormones. Invitations to submit Brief Reviews are issued to specific authors by the Editors.
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