子宫内膜异位症动物模型的临床前证据介绍。

4区 生物学 Q3 Medicine
Kathy L Sharpe-Timms, Julie A W Stilley
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引用次数: 1

摘要

子宫内膜异位症,子宫内膜腺上皮细胞和间质细胞在子宫腔外的存在和生长,导致育龄妇女和女孩疼痛和不孕。由于女性子宫内膜异位症的随机、双盲、对照研究是不切实际的,有时在伦理上是禁止的,子宫内膜异位症的动物模型作为一种重要的辅助手段,可以深入了解这种令人困惑的疾病的病因和病理生理机制。对女性子宫内膜异位症更深入的了解可能有助于开发新的无创诊断、分类系统、治疗方案,甚至预防方法来管理子宫内膜异位症。本章旨在简要介绍子宫内膜异位症的历史背景、生物学和流行病学方面、主要症状、内分泌干扰化学物质的影响,以及妇女子宫内膜异位症的表观遗传因素的一个例子。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Introduction to Preclinical Evidence from Animal Models of Endometriosis.

Endometriosis, the presence and growth of uterine endometrial glandular epithelial and stroma cells outside the uterine cavity, causes pain and infertility in women and girls of reproductive age. As randomized, double-blinded, controlled studies of endometriosis in women are impractical and at times ethically prohibitive, animal models for endometriosis arose as an important adjunct to gain mechanistic insights into the etiology and pathophysiological mechanisms of this perplexing disorder. A more thorough understanding of endometriosis in women may help develop novel noninvasive diagnostics, classification systems, therapeutic regimes, and even preventative methods for the management of endometriosis. This chapter is intended to introduce a brief historical background, biological and epidemiological aspects, the major symptoms, the effects of endocrine-disrupting chemicals, and an example of an epigenetic factor of endometriosis in women.

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来源期刊
CiteScore
2.00
自引率
0.00%
发文量
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期刊介绍: "Advances in Anatomy, Embryology and Cell Biology" presents critical reviews on all topical fields of normal and experimental anatomy including cell biology. The multi-perspective presentation of morphological aspects of basic biological phenomen in the human constitutes the main focus of the series. The contributions re-evaluate the latest findings and show ways for further research.
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