长链非编码RNA HOTAIR变异对伊朗妇女子痫前期易感性的贡献

IF 1.5 4区医学 Q3 OBSTETRICS & GYNECOLOGY

Hypertension in Pregnancy Pub Date : 2021-02-01 Epub Date: 2020-12-02 DOI:10.1080/10641955.2020.1855192

Sahra Esmkhani, Hossein Sadeghi, Majid Ghasemian, Reihaneh Pirjani, Mona Amin-Beidokhti, Milad Gholami, Fakhrolmolouk Yassaee, Reza Mirfakhraie

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引用次数: 3

摘要

目的:探讨伊朗人群中lncRNA HOTAIR rs920778和rs874945多态性与子痫前期风险的可能关联。方法:选取250例子痫前期妇女和250例健康妇女作为研究对象。采用TP-ARMS-PCR方法对rs920778和rs874945多态性进行基因分型。结果:HOTAIR rs920778在显性和隐性遗传模式下增加子痫前期的风险(OR = 4.84, 95% CI: 3.30-7.10, P)。结论:本研究证实了HOTAIR rs920778多态性与伊朗女性子痫前期的相关性。需要进一步的研究来证实我们的发现。

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Contribution of long noncoding RNA HOTAIR variants to preeclampsia susceptibility in Iranian women.

Objective: To investigate the possible association of lncRNA HOTAIR rs920778 and rs874945 polymorphisms with preeclampsia risk in a sample from the Iranian population. Method: The study subjects included 250 preeclamptic women and 250 healthy women. The genotyping for rs920778 and rs874945 polymorphisms were performed using the TP-ARMS-PCR method. Results: HOTAIR rs920778 increased the risk of preeclampsia under the dominant and recessive inheritance patterns (OR = 4.84, 95% CI: 3.30-7.10, P < 0.0001; OR = 6.86, 95% CI: 3.51-13.42, P < 0.0001; respectively). Conclusion: This study confirmed the association of HOTAIR rs920778 polymorphism with preeclampsia in Iranian women. Further studies should be performed to confirm our findings.

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来源期刊

Hypertension in Pregnancy 医学-妇产科学

CiteScore

3.40

自引率

0.00%

发文量

审稿时长

6 months

期刊介绍： Hypertension in Pregnancy is a refereed journal in the English language which publishes data pertaining to human and animal hypertension during gestation. Contributions concerning physiology of circulatory control, pathophysiology, methodology, therapy or any other material relevant to the relationship between elevated blood pressure and pregnancy are acceptable. Published material includes original articles, clinical trials, solicited and unsolicited reviews, editorials, letters, and other material deemed pertinent by the editors.