细胞增殖抑制剂和细胞凋亡促进剂

Q3 Medicine

Ejc Supplements Pub Date : 2020-08-01 DOI:10.1016/j.ejcsup.2019.09.002

J. Alejandro Perez-Fidalgo

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引用次数: 5

摘要

癌症的特点是不受控制的增殖和细胞存活时间延长。在某些情况下，肿瘤的形成是由于各种细胞周期调节因子的异常活动导致染色体不稳定或细胞凋亡途径的改变。卵巢癌是一种细胞周期改变是常见的实体。P53是检查点G1的关键调节因子，在高级别浆液性卵巢癌中经常发生改变。靶向细胞周期调节因子将导致这些肿瘤中的有丝分裂灾难和细胞死亡。促进细胞凋亡是卵巢癌的另一个靶点。本文综述了靶向细胞周期或促进细胞凋亡的化合物在卵巢癌临床研究中的最相关证据。

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Cell proliferation inhibitors and apoptosis promoters

Cancer is characterised by uncontrolled proliferation and prolonged cell survival. In some cases, tumour formation is the result from aberrant activity of various cell-cycle regulators leading to chromosome instability or from alteration of the apoptosis pathway. Ovarian cancer is an entity in which cell-cycle alterations are common. P53, a key regulator of checkpoint G1, is frequently altered in high-grade serous ovarian cancer. Targeting cell-cycle regulators will lead to mitotic catastrophe and cell death in these tumours. Promoting apoptosis is another target that is gaining interest in ovarian cancer.

In this review, the most relevant evidence of clinical studies in ovarian cancer with compounds targeting cell cycle or promoting apoptosis is summarised.

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来源期刊

Ejc Supplements 医学-肿瘤学

自引率

0.00%

发文量

审稿时长

3.7 months

期刊介绍： EJC Supplements is an open access companion journal to the European Journal of Cancer. As an open access journal, all published articles are subject to an Article Publication Fee. Immediately upon publication, all articles in EJC Supplements are made openly available through the journal''s websites. EJC Supplements will consider for publication the proceedings of scientific symposia, commissioned thematic issues, and collections of invited articles on preclinical and basic cancer research, translational oncology, clinical oncology and cancer epidemiology and prevention. Authors considering the publication of a supplement in EJC Supplements are requested to contact the Editorial Office of the EJC to discuss their proposal with the Editor-in-Chief. EJC Supplements is an official journal of the European Organisation for Research and Treatment of Cancer (EORTC), the European CanCer Organisation (ECCO) and the European Society of Mastology (EUSOMA).