用即时核磁共振系统分析糖尿病氧化应激的分子表型。

IF 5.4 Q1 GERIATRICS & GERONTOLOGY
NPJ Aging and Mechanisms of Disease Pub Date : 2020-10-05 eCollection Date: 2020-01-01 DOI:10.1038/s41514-020-00049-0
Weng Kung Peng, Lan Chen, Bernhard O Boehm, Jongyoon Han, Tze Ping Loh
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引用次数: 8

摘要

糖尿病是全球增长最快的健康负担之一。氧化应激与糖尿病并发症(如心血管事件)的发病机制有关,但对其了解甚少。我们报告了一种使用即时核磁共振系统快速操作和评估血液氧化还原状态的新方法。血红蛋白的各种氧化还原状态使用新提出的(伪)二维图被称为T1-T2磁状态图。我们利用氧化应激改变了血液中水质子的细微分子运动,从而引起磁共振弛豫特性的可测量的变化这一事实。我们展示了该技术的临床应用,可以根据氧化状态和传统血糖水平对糖尿病患者进行快速分层,从而改善患者分层,从而改善临床糖尿病护理和管理的总体结果。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Molecular phenotyping of oxidative stress in diabetes mellitus with point-of-care NMR system.

Molecular phenotyping of oxidative stress in diabetes mellitus with point-of-care NMR system.

Molecular phenotyping of oxidative stress in diabetes mellitus with point-of-care NMR system.

Molecular phenotyping of oxidative stress in diabetes mellitus with point-of-care NMR system.

Diabetes mellitus is one of the fastest-growing health burdens globally. Oxidative stress, which has been implicated in the pathogenesis of diabetes complication (e.g., cardiovascular event), remains poorly understood. We report a new approach to rapidly manipulate and evaluate the redox states of blood using a point-of-care NMR system. Various redox states of the hemoglobin were mapped out using the newly proposed (pseudo) two-dimensional map known as T1-T2 magnetic state diagram. We exploit the fact that oxidative stress changes the subtle molecular motion of water proton in the blood, and thus inducing a measurable shift in magnetic resonance relaxation properties. We demonstrated the clinical utilities of this technique to rapidly stratify diabetes subjects based on their oxidative status in conjunction to the traditional glycemic level to improve the patient stratification and thus the overall outcome of clinical diabetes care and management.

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来源期刊
NPJ Aging and Mechanisms of Disease
NPJ Aging and Mechanisms of Disease Medicine-Geriatrics and Gerontology
自引率
0.00%
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0
审稿时长
8 weeks
期刊介绍: npj Aging and Mechanisms of Disease is an online open access journal that provides a forum for the world’s most important research in the fields of aging and aging-related disease. The journal publishes papers from all relevant disciplines, encouraging those that shed light on the mechanisms behind aging and the associated diseases. The journal’s scope includes, but is not restricted to, the following areas (not listed in order of preference): • cellular and molecular mechanisms of aging and aging-related diseases • interventions to affect the process of aging and longevity • homeostatic regulation and aging • age-associated complications • translational research into prevention and treatment of aging-related diseases • mechanistic bases for epidemiological aspects of aging-related disease.
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