胞吞作用在适应细胞应激中的作用。

IF 4.1 Q2 CELL BIOLOGY
Tania López-Hernández, Volker Haucke, Tanja Maritzen
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引用次数: 27

摘要

细胞生命受到多种应激条件的挑战,例如由渗透压、氧气或营养供应的变化引发。因此,细胞已经发展出复杂的应激反应来应对这些挑战。其中一些应激程序,如热休克反应,已经得到了非常详细的了解,而其他方面,包括质膜蛋白质组潜在的应激依赖性适应,在很大程度上仍然是难以捉摸的。质膜不仅是许多类型的环境胁迫的第一个接触点,而且考虑到受体蛋白及其相关分子的多样性,质膜也代表了许多细胞信号级联产生的位点。由于这些信号通路几乎影响细胞生命的所有方面,质膜蛋白质组的变化似乎非常适合于促进细胞适应压力。改变细胞表面蛋白质组以应对压力的最快速方法是改变内吞作用。总的内吞通量或内吞调节选择蛋白质的变化可以帮助抵消不利的环境条件。在这篇综述中,我们总结了最近关于应激诱导的内吞作用变化的数据,并讨论了这些变化如何有助于不同系统的细胞适应应激。未来的研究将需要详细揭示潜在的机制,并得出一个连贯的画面。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Endocytosis in the adaptation to cellular stress.

Endocytosis in the adaptation to cellular stress.

Endocytosis in the adaptation to cellular stress.

Endocytosis in the adaptation to cellular stress.

Cellular life is challenged by a multitude of stress conditions, triggered for example by alterations in osmolarity, oxygen or nutrient supply. Hence, cells have developed sophisticated stress responses to cope with these challenges. Some of these stress programs such as the heat shock response are understood in great detail, while other aspects remain largely elusive including potential stress-dependent adaptations of the plasma membrane proteome. The plasma membrane is not only the first point of encounter for many types of environmental stress, but given the diversity of receptor proteins and their associated molecules also represents the site at which many cellular signal cascades originate. Since these signaling pathways affect virtually all aspects of cellular life, changes in the plasma membrane proteome appear ideally suited to contribute to the cellular adaptation to stress. The most rapid means to alter the cell surface proteome in response to stress is by alterations in endocytosis. Changes in the overall endocytic flux or in the endocytic regulation of select proteins conceivably can help to counteract adverse environmental conditions. In this review we summarize recent data regarding stress-induced changes in endocytosis and discuss how these changes might contribute to the cellular adaptation to stress in different systems. Future studies will be needed to uncover the underlying mechanisms in detail and to arrive at a coherent picture.

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来源期刊
Cell Stress
Cell Stress Biochemistry, Genetics and Molecular Biology-Biochemistry, Genetics and Molecular Biology (miscellaneous)
CiteScore
13.50
自引率
0.00%
发文量
21
审稿时长
15 weeks
期刊介绍: Cell Stress is an open-access, peer-reviewed journal that is dedicated to publishing highly relevant research in the field of cellular pathology. The journal focuses on advancing our understanding of the molecular, mechanistic, phenotypic, and other critical aspects that underpin cellular dysfunction and disease. It specifically aims to foster cell biology research that is applicable to a range of significant human diseases, including neurodegenerative disorders, myopathies, mitochondriopathies, infectious diseases, cancer, and pathological aging. The scope of Cell Stress is broad, welcoming submissions that represent a spectrum of research from fundamental to translational and clinical studies. The journal is a valuable resource for scientists, educators, and policymakers worldwide, as well as for any individual with an interest in cellular pathology. It serves as a platform for the dissemination of research findings that are instrumental in the investigation, classification, diagnosis, and therapeutic management of major diseases. By being open-access, Cell Stress ensures that its content is freely available to a global audience, thereby promoting international scientific collaboration and accelerating the exchange of knowledge within the research community.
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