由于N基因的单点突变，SARS-CoV-2样本可能会逃避检测。

IF 7.8

Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin Pub Date : 2020-10-01 DOI:10.2807/1560-7917.ES.2020.25.39.2001650

Katharina Ziegler, Philipp Steininger, Renate Ziegler, Jörg Steinmann, Klaus Korn, Armin Ensser

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引用次数: 106

摘要

我们发现来自一名患者的严重急性呼吸综合征冠状病毒2 (SARS-CoV-2)核蛋白基因的单核苷酸多态性(SNP)干扰了一项广泛使用的商业检测。EpiCoV数据库中大约0.2%的分离株含有这种SNP。尽管在实验中，SARS-CoV-2仍然被另一个探针检测到，但这强调了针对病原体的两个独立基本区域进行可靠检测的必要性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

SARS-CoV-2 samples may escape detection because of a single point mutation in the N gene.

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SARS-CoV-2 samples may escape detection because of a single point mutation in the N gene.

We found that a single nucleotide polymorphism (SNP) in the nucleoprotein gene of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) from a patient interfered with detection in a widely used commercial assay. Some 0.2% of the isolates in the EpiCoV database contain this SNP. Although SARS-CoV-2 was still detected by the other probe in the assay, this underlines the necessity of targeting two independent essential regions of a pathogen for reliable detection.

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Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin

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