真核生物DNA复制过程中聚合酶分工的最新研究进展。

IF 6.2 2区生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Critical Reviews in Biochemistry and Molecular Biology Pub Date : 2020-10-01 Epub Date: 2020-09-03 DOI:10.1080/10409238.2020.1811630

Thomas A Guilliam, Joseph T P Yeeles

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引用次数: 28

摘要

在真核生物中，α、δ和ε三种DNA聚合酶在基因组复制过程中负责新生链的大量DNA合成。大多数证据支持Pol α在Pol ε和Pol δ分别复制前导链和滞后链之前启动DNA合成的模型。然而，由于生物化学和遗传技术的进步，最近的一些报道强调了Pol δ在先导链合成的各个阶段的新作用;起始，延伸和终止，以及分叉重新启动。通过这些研究，本文综述了DNA复制过程中复制聚合酶之间分工的最新观点。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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An updated perspective on the polymerase division of labor during eukaryotic DNA replication.

In eukaryotes three DNA polymerases (Pols), α, δ, and ε, are tasked with bulk DNA synthesis of nascent strands during genome duplication. Most evidence supports a model where Pol α initiates DNA synthesis before Pol ε and Pol δ replicate the leading and lagging strands, respectively. However, a number of recent reports, enabled by advances in biochemical and genetic techniques, have highlighted emerging roles for Pol δ in all stages of leading-strand synthesis; initiation, elongation, and termination, as well as fork restart. By focusing on these studies, this review provides an updated perspective on the division of labor between the replicative polymerases during DNA replication.

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来源期刊

Critical Reviews in Biochemistry and Molecular Biology 生物-生化与分子生物学

CiteScore

14.90

自引率

0.00%

发文量

期刊介绍： As the discipline of biochemistry and molecular biology have greatly advanced in the last quarter century, significant contributions have been made towards the advancement of general medicine, genetics, immunology, developmental biology, and biophysics. Investigators in a wide range of disciplines increasingly require an appreciation of the significance of current biochemical and molecular biology advances while, members of the biochemical and molecular biology community itself seek concise information on advances in areas remote from their own specialties. Critical Reviews in Biochemistry and Molecular Biology believes that well-written review articles prove an effective device for the integration and meaningful comprehension of vast, often contradictory, literature. Review articles also provide an opportunity for creative scholarship by synthesizing known facts, fruitful hypotheses, and new concepts. Accordingly, Critical Reviews in Biochemistry and Molecular Biology publishes high-quality reviews that organize, evaluate, and present the current status of high-impact, current issues in the area of biochemistry and molecular biology. Topics are selected on the advice of an advisory board of outstanding scientists, who also suggest authors of special competence. The topics chosen are sufficiently broad to interest a wide audience of readers, yet focused enough to be within the competence of a single author. Authors are chosen based on their activity in the field and their proven ability to produce a well-written publication.