配体辅助的烯烃与自组装亚胺实现的分子氧切换发散氧化Heck级联†

Organic chemistry frontiers : an international journal of organic chemistry Pub Date : 2023-01-01 DOI:10.1039/d3qo00316g

Bairong Liu , Jianhang Rao , Weibing Liu , Yang Gao , Yanping Huo , Qian Chen , Xianwei Li

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引用次数: 0

摘要

分散氧化Heck反应已被证明是快速构建分子复杂性的可靠方法，而烯烃则改变了尚未充分探索的结果。在此，烯烃通过自组装亚胺调节了与O2的发散氧化Heck反应，这是通过具有位点选择性和立体选择性实现的。强配位吡啶和喹啉的相容性使选择性血清素4受体配体拓扑替康和伊立替康类似物能够简洁地递送。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Ligand-assisted olefin-switched divergent oxidative Heck cascade with molecular oxygen enabled by self-assembled imines†

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Ligand-assisted olefin-switched divergent oxidative Heck cascade with molecular oxygen enabled by self-assembled imines†

Divergent oxidative Heck reaction has proven to be reliable for the rapid construction of molecular complexity, while olefins switched the outcome that remained underexplored. Herein, olefins tuned the divergent oxidative Heck reaction with O₂, enabled by self-assembled imines, which was achieved with site selectivity and stereoselectivity. The compatiblity of strongly coordinating pyridines and quinolines enabled the concise delivery of a selective serotonin 4 receptor ligand, topotecan, and irinotecan analogues.

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来源期刊

Organic chemistry frontiers : an international journal of organic chemistry

CiteScore

7.80

自引率

0.00%

发文量