冬眠的细胞、分子和生理适应:环境挑战的解决方案。

IF 11.4 1区 生物学 Q1 CELL BIOLOGY
Sarah M Mohr, Sviatoslav N Bagriantsev, Elena O Gracheva
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引用次数: 37

摘要

在资源稀缺的时代,繁荣需要行为、生理、细胞和分子功能的不可思议的灵活性,这些功能必须在相对较短的时间内改变。冬眠是一种生理策略的集合,使动物能够居住在恶劣的环境中,在那里它们经历了极端的热挑战和食物和水的匮乏。许多不同种类的动物都有冬眠,并且有一系列的冬眠表型。在这里,我们将重点关注强制性的哺乳动物冬眠,以确定它们面临的独特挑战以及使冬眠者能够克服这些挑战的适应性。这包括用于对抗低环境和体温以及缺乏食物和水的细胞和分子策略。我们将讨论调节冬眠的代谢、神经元和激素线索,以及它们如何被认为是由内部时钟协调的。最后,我们谈到了冬眠研究领域有待解决的问题。上个世纪的研究和最近的工作表明,冬眠不仅仅是体温和重要参数的被动降低,而是一个在分子、细胞和有机体水平上季节性调节的主动过程。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Cellular, Molecular, and Physiological Adaptations of Hibernation: The Solution to Environmental Challenges.

Thriving in times of resource scarcity requires an incredible flexibility of behavioral, physiological, cellular, and molecular functions that must change within a relatively short time. Hibernation is a collection of physiological strategies that allows animals to inhabit inhospitable environments, where they experience extreme thermal challenges and scarcity of food and water. Many different kinds of animals employ hibernation, and there is a spectrum of hibernation phenotypes. Here, we focus on obligatory mammalian hibernators to identify the unique challenges they face and the adaptations that allow hibernators to overcome them. This includes the cellular and molecular strategies used to combat low environmental and body temperatures and lack of food and water. We discuss metabolic, neuronal, and hormonal cues that regulate hibernation and how they are thought to be coordinated by internal clocks. Last, we touch on questions that are left to be addressed in the field of hibernation research. Studies from the last century and more recent work reveal that hibernation is not simply a passive reduction in body temperature and vital parameters but rather an active process seasonally regulated at the molecular, cellular, and organismal levels.

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来源期刊
CiteScore
19.50
自引率
0.00%
发文量
21
期刊介绍: The Annual Review of Cell and Developmental Biology, established in 1985, comprehensively addresses major advancements in cell and developmental biology. Encompassing the structure, function, and organization of cells, as well as the development and evolution of cells in relation to both single and multicellular organisms, the journal explores models and tools of molecular biology. As of the current volume, the journal has transitioned from gated to open access through Annual Reviews' Subscribe to Open program, making all articles published under a CC BY license.
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