活性氧对免疫系统的影响及多发性硬化的发病机制。

IF 1.7 Q4 IMMUNOLOGY
Autoimmune Diseases Pub Date : 2020-06-25 eCollection Date: 2020-01-01 DOI:10.1155/2020/5793817
Mohammad Javad Tavassolifar, Mohammad Vodjgani, Zahra Salehi, Maryam Izad
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引用次数: 60

摘要

近年来,活性氧(reactive oxygen species, ROS)在免疫系统中的多种作用已被证实。活性氧由于其破坏DNA和其他亚细胞结构的能力而被广泛研究。值得注意的是,它们已被确定为t细胞受体信号传导和t细胞活化的关键第二信使,并参与抗原交叉呈递和趋化。作为一种对细胞具有直接毒性作用的药物,ROS可导致自身免疫反应的启动。此外,ROS水平受抗氧化系统的调节,包括酶和非酶抗氧化剂。酶促抗氧化剂包括超氧化物歧化酶、过氧化氢酶、谷胱甘肽过氧化物酶和谷胱甘肽还原酶。非酶抗氧化剂含有维生素C、A和E、谷胱甘肽和硫氧还蛋白。特别是,细胞抗氧化系统在维持氧化还原系统稳态方面具有重要的功能。本文将讨论正常情况下ROS生成和抗氧化系统在免疫系统中的重要作用,以及多发性硬化症的发病机制。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

The Influence of Reactive Oxygen Species in the Immune System and Pathogenesis of Multiple Sclerosis.

The Influence of Reactive Oxygen Species in the Immune System and Pathogenesis of Multiple Sclerosis.

The Influence of Reactive Oxygen Species in the Immune System and Pathogenesis of Multiple Sclerosis.

The Influence of Reactive Oxygen Species in the Immune System and Pathogenesis of Multiple Sclerosis.

Multiple roles have been indicated for reactive oxygen species (ROS) in the immune system in recent years. ROS have been extensively studied due to their ability to damage DNA and other subcellular structures. Noticeably, they have been identified as a pivotal second messenger for T-cell receptor signaling and T-cell activation and participate in antigen cross-presentation and chemotaxis. As an agent with direct toxic effects on cells, ROS lead to the initiation of the autoimmune response. Moreover, ROS levels are regulated by antioxidant systems, which include enzymatic and nonenzymatic antioxidants. Enzymatic antioxidants include superoxide dismutase, catalase, glutathione peroxidase, and glutathione reductase. Nonenzymatic antioxidants contain vitamins C, A, and E, glutathione, and thioredoxin. Particularly, cellular antioxidant systems have important functions in maintaining the redox system homeostasis. This review will discuss the significant roles of ROS generation and antioxidant systems under normal conditions, in the immune system, and pathogenesis of multiple sclerosis.

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来源期刊
Autoimmune Diseases
Autoimmune Diseases IMMUNOLOGY-
CiteScore
6.10
自引率
0.00%
发文量
9
审稿时长
17 weeks
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