{"title":"敲除PINK1改变了果蝇多巴胺PPM3神经元输入和输出位点的神经连通性。","authors":"Jing-Da Qiao, Yu-Ling Mao","doi":"10.1007/s10158-020-00244-4","DOIUrl":null,"url":null,"abstract":"<p><p>Impairment of the dopamine system is the main cause of Parkinson disease (PD). PTEN-induced kinase 1 (PINK1) is possibly involved in pathogenesis of PD. However, its role in dopaminergic neurons has not been fully established yet. In the present investigation, we have used the PINK1 knockout Drosophila model to explore the role of PINK1 in dopaminergic neurons. Electrophysiological and behavioral tests indicated that PINK1 elimination enhances the neural transmission from the presynaptic part of dopaminergic neurons in the protocerebral posterior medial region 3 (PPM3) to PPM3 neurons (which are homologous to those in the substantia nigra in humans). Firing properties of the action potential in PPM3 neurons were also altered in the PINK1 knockout genotypes. Abnormal motor ability was also observed in these PINK1 knockout animals. Our results indicate that knockout of PINK1 could alter both the input and output properties of PPM3 neurons.</p>","PeriodicalId":14430,"journal":{"name":"Invertebrate Neuroscience","volume":"20 3","pages":"11"},"PeriodicalIF":0.0000,"publicationDate":"2020-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s10158-020-00244-4","citationCount":"6","resultStr":"{\"title\":\"Knockout of PINK1 altered the neural connectivity of Drosophila dopamine PPM3 neurons at input and output sites.\",\"authors\":\"Jing-Da Qiao, Yu-Ling Mao\",\"doi\":\"10.1007/s10158-020-00244-4\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Impairment of the dopamine system is the main cause of Parkinson disease (PD). PTEN-induced kinase 1 (PINK1) is possibly involved in pathogenesis of PD. However, its role in dopaminergic neurons has not been fully established yet. In the present investigation, we have used the PINK1 knockout Drosophila model to explore the role of PINK1 in dopaminergic neurons. Electrophysiological and behavioral tests indicated that PINK1 elimination enhances the neural transmission from the presynaptic part of dopaminergic neurons in the protocerebral posterior medial region 3 (PPM3) to PPM3 neurons (which are homologous to those in the substantia nigra in humans). Firing properties of the action potential in PPM3 neurons were also altered in the PINK1 knockout genotypes. Abnormal motor ability was also observed in these PINK1 knockout animals. Our results indicate that knockout of PINK1 could alter both the input and output properties of PPM3 neurons.</p>\",\"PeriodicalId\":14430,\"journal\":{\"name\":\"Invertebrate Neuroscience\",\"volume\":\"20 3\",\"pages\":\"11\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2020-08-06\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1007/s10158-020-00244-4\",\"citationCount\":\"6\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Invertebrate Neuroscience\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1007/s10158-020-00244-4\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"Neuroscience\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Invertebrate Neuroscience","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1007/s10158-020-00244-4","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"Neuroscience","Score":null,"Total":0}
Knockout of PINK1 altered the neural connectivity of Drosophila dopamine PPM3 neurons at input and output sites.
Impairment of the dopamine system is the main cause of Parkinson disease (PD). PTEN-induced kinase 1 (PINK1) is possibly involved in pathogenesis of PD. However, its role in dopaminergic neurons has not been fully established yet. In the present investigation, we have used the PINK1 knockout Drosophila model to explore the role of PINK1 in dopaminergic neurons. Electrophysiological and behavioral tests indicated that PINK1 elimination enhances the neural transmission from the presynaptic part of dopaminergic neurons in the protocerebral posterior medial region 3 (PPM3) to PPM3 neurons (which are homologous to those in the substantia nigra in humans). Firing properties of the action potential in PPM3 neurons were also altered in the PINK1 knockout genotypes. Abnormal motor ability was also observed in these PINK1 knockout animals. Our results indicate that knockout of PINK1 could alter both the input and output properties of PPM3 neurons.
期刊介绍：
Invertebrate Neurosciences publishes peer-reviewed original articles, reviews and technical reports describing recent advances in the field of invertebrate neuroscience. The journal reports on research that exploits the simplicity and experimental tractability of the invertebrate preparations to underpin fundamental advances in neuroscience. Articles published in Invertebrate Neurosciences serve to highlight properties of signalling in the invertebrate nervous system that may be exploited in the field of antiparisitics, molluscicides and insecticides. Aspects of particular interest include:
Functional analysis of the invertebrate nervous system;
Molecular neuropharmacology and toxicology;
Neurogenetics and genomics;
Functional anatomy;
Neurodevelopment;
Neuronal networks;
Molecular and cellular mechanisms of behavior and behavioural plasticity.
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