2019年血液和骨髓移植临床试验网络骨髓瘤最小残留病和免疫谱组间研讨会总结

IF 4.3 Q1 Medicine
Sarah A. Holstein , Alan Howard , David Avigan , Manisha Bhutani , Adam D. Cohen , Luciano J. Costa , Madhav V. Dhodapkar , Francesca Gay , Nicole Gormley , Damian J. Green , Jens Hillengass , Neha Korde , Zihai Li , Sham Mailankody , Paola Neri , Samir Parekh , Marcelo C. Pasquini , Noemi Puig , G. David Roodman , Mehmet Kemal Samur , Philip L. McCarthy
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引用次数: 9

摘要

自2016年以来,血液和骨髓移植临床试验网络(BMT CTN)骨髓瘤Intergroup组织了一年一度的研讨会,重点关注多发性骨髓瘤的最小残留病(MRD)检测和免疫分析(IP)。2019年,该研讨会作为美国血液学学会(ASH)周五科学研讨会举行,题为“多发性骨髓瘤的免疫分析和最小残留疾病检测”。本次研讨会集中讨论了4个主要议题:浆细胞疾病的分子和免疫学进化,基于实验室和成像的MRD评估新方法的发展,嵌合抗原受体T细胞治疗研究,以及与新型临床终点相关的统计和监管问题。在本报告中,我们对研讨会进行了总结,并讨论了未来的发展方向。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Summary of the 2019 Blood and Marrow Transplant Clinical Trials Network Myeloma Intergroup Workshop on Minimal Residual Disease and Immune Profiling

The Blood and Marrow Transplant Clinical Trials Network (BMT CTN) Myeloma Intergroup has organized an annual workshop focused on minimal residual disease (MRD) testing and immune profiling (IP) in multiple myeloma since 2016. In 2019, the workshop took place as an American Society of Hematology (ASH) Friday Scientific Workshop titled “Immune Profiling and Minimal Residual Disease Testing in Multiple Myeloma.” This workshop focused on 4 main topics: the molecular and immunologic evolution of plasma cell disorders, development of new laboratory- and imaging-based MRD assessment approaches, chimeric antigen receptor T cell therapy research, and statistical and regulatory issues associated with novel clinical endpoints. In this report, we provide a summary of the workshop and discuss future directions.

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来源期刊
CiteScore
6.60
自引率
0.00%
发文量
1061
审稿时长
3-6 weeks
期刊介绍: Biology of Blood and Marrow Transplantation publishes original research reports, reviews, editorials, commentaries, letters to the editor, and hypotheses and is the official publication of the American Society for Transplantation and Cellular Therapy. The journal focuses on current technology and knowledge in the interdisciplinary field of hematopoetic stem cell transplantation.
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