驱动蛋白8马达:微管动力学和染色体运动的调节。

IF 2.5 4区生物学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY

Chromosoma Pub Date : 2020-06-01 Epub Date: 2020-05-17 DOI:10.1007/s00412-020-00736-7

Yang Lin, Ya-Lan Wei, Zhen-Yu She

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引用次数: 6

摘要

在细胞分裂过程中，微管对细胞内运输、细胞运动、纺锤体组装和染色体分离至关重要。微管动力学调节纺锤体的正确组织，从而有助于染色体的聚集和分离。越来越多的研究表明，kinesin-8马达是微管动力学和组织的新兴调节剂。本文就细胞分裂过程中运动蛋白-8马达的研究进展作一综述。我们讨论了kinesin-8马达的结构和分子动力学。我们强调了激酶-8在微管动力学和纺锤体组织调节中的重要作用和机制。我们还阐明了细胞周期中驱动蛋白-8马达在染色体运动和纺锤体组装检查点中的功能。

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Kinesin-8 motors: regulation of microtubule dynamics and chromosome movements.

Microtubules are essential for intracellular transport, cell motility, spindle assembly, and chromosome segregation during cell division. Microtubule dynamics regulate the proper spindle organization and thus contribute to chromosome congression and segregation. Accumulating studies suggest that kinesin-8 motors are emerging regulators of microtubule dynamics and organizations. In this review, we provide an overview of the studies focused on kinesin-8 motors in cell division. We discuss the structures and molecular kinetics of kinesin-8 motors. We highlight the essential roles and mechanisms of kinesin-8 in the regulation of microtubule dynamics and spindle organization. We also shed light on the functions of kinesin-8 motors in chromosome movement and the spindle assembly checkpoint during the cell cycle.

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来源期刊

Chromosoma 生物-生化与分子生物学

CiteScore

3.30

自引率

6.20%

发文量

审稿时长

1 months

期刊介绍： Chromosoma publishes research and review articles on the functional organization of the eukaryotic cell nucleus, with a particular emphasis on the structure and dynamics of chromatin and chromosomes; the expression and replication of genomes; genome organization and evolution; the segregation of genomes during meiosis and mitosis; the function and dynamics of subnuclear compartments; the nuclear envelope and nucleocytoplasmic interactions, and more. The scope of Chromosoma encompasses genetic, biophysical, molecular and cell biological studies. Average time from receipt of contributions to first decision: 22 days Publishes research and review articles on the functional organization of the eukaryotic cell nucleus Topics include structure and dynamics of chromatin and chromosomes; the expression and replication of genomes; genome organization and evolution; the segregation of genomes during meiosis and mitosis and more Encompasses genetic, biophysical, molecular and cell biological studies.