酒精与多发性硬化症:基于免疫系统的综述。

International journal of physiology, pathophysiology and pharmacology Pub Date : 2020-04-15 eCollection Date: 2020-01-01
Maryam Fahim, Aryan Rafiee Zadeh, Pouria Shoureshi, Keyvan Ghadimi, Masoumeh Cheshmavar, Neda Sheikhinia, Mahdieh Afzali
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引用次数: 0

摘要

多发性硬化症是中枢神经系统(CNS)的一种慢性炎症性疾病。虽然多发性硬化症的确切病因尚不清楚,但研究人员认为,遗传、环境和微生物因素在导致多发性硬化症方面起着核心作用。多发性硬化症的病理基础是炎症,因为 T 细胞通过破坏血脑屏障进入大脑,将髓鞘识别为外来抗原;结果,T 细胞攻击髓鞘,启动炎症过程,增强炎症细胞因子和抗体。由于之前的研究表明乙醇可以抑制免疫系统,如先天免疫、体液免疫和细胞免疫,并增加抗炎细胞因子的产生,因此我们假设乙醇可能对多发性硬化症状也有改善作用。虽然酒精会诱导少突胶质细胞和神经元凋亡,导致脱髓鞘,并直接影响中枢神经系统,但在本研究中,我们将探讨乙醇对多发性硬化症患者免疫系统某些方面的影响。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Alcohol and multiple sclerosis: an immune system-based review.

Multiple sclerosis is a chronic inflammatory disease of the central nervous system (CNS). Although the exact etiology of multiple sclerosis is unknown, researchers suggest that genetic, environmental, and microbial factors play a central role in causing multiple sclerosis. Pathology of multiple sclerosis is based on inflammation as T cells enter the brain via disruptions in the blood-brain barrier, recognizing myelin as foreign antigen; and as a result, the T cells attack myelin and start the inflammatory processes, enhancing inflammatory cytokines and antibodies. Since previous studies show ethanol can suppress the immune system such as innate, humoral, and cellular immunity and increases the production of anti-inflammatory cytokines, we hypothesized maybe ethanol also have ameliorating effects on multiple sclerosis symptoms. Although alcohol induces apoptosis in oligodendrocytes and neurons, causing demyelination and affects CNS directly, in this study we will investigate ethanol's effects on some aspects of the immune system in multiple sclerosis.

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