植物衍生产品作为基质金属蛋白酶抑制剂在心血管疾病中的应用。

IF 1.5 Q3 PERIPHERAL VASCULAR DISEASE
Alejandro F do Prado, Cahy M Bannwart, Victoria M T Shinkai, Ildercílio M de Souza Lima, César A Meschiari
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引用次数: 0

摘要

基质金属蛋白酶(MMPs)是在其结构中呈现金属元素的酶。这些酶是普遍分布和功能作为细胞外基质(ECM)重塑。MMPs在心血管生物学调控过程中发挥着广泛的作用,如细胞粘附和功能、细胞通讯和分化、机械力和力传递的整合、组织重塑、受损组织结构完整性的调节、细胞存活或凋亡以及炎症相关细胞因子和生长因子的调节。MMPs的抑制和下调与心脏损伤的最小化相关,即中草药因其抗炎、抗氧化和MMP-2和9抑制特性而被证明具有稳定腹主动脉动脉瘤的作用。因此,植物衍生产品有望成为关注MMPs抑制和下调以治疗或预防心血管疾病的新疗法的来源。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Phyto-derived Products as Matrix Metalloproteinases Inhibitors in Cardiovascular Diseases.

Matrix metalloproteinases (MMPs) are enzymes that present a metallic element in their structure. These enzymes are ubiquitously distributed and function as extracellular matrix (ECM) remodelers. MMPs play a broad role in cardiovascular biology regulating processes such as cell adhesion and function, cellular communication and differentiation, integration of mechanical force and force transmission, tissue remodeling, modulation of damaged-tissue structural integrity, cellular survival or apoptosis and regulation of inflammation-related cytokines and growth factors. MMPs inhibition and downregulation are correlated with minimization of cardiac damage, i.e., Chinese herbal medicine has shown to stabilize abdominal aorta aneurysm due to its antiinflammatory, antioxidant and MMP-2 and 9 inhibitory properties. Thus phyto-derived products rise as promising sources for novel therapies focusing on MMPs inhibition and downregulation to treat or prevent cardiovascular disorders.

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来源期刊
Current Hypertension Reviews
Current Hypertension Reviews PERIPHERAL VASCULAR DISEASE-
CiteScore
4.80
自引率
0.00%
发文量
26
期刊介绍: Current Hypertension Reviews publishes frontier reviews/ mini-reviews, original research articles and guest edited thematic issues on all the latest advances on hypertension and its related areas e.g. nephrology, clinical care, and therapy. The journal’s aim is to publish the highest quality review articles dedicated to clinical research in the field. The journal is essential reading for all clinicians and researchers in the field of hypertension.
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