哺乳动物细胞对渗透胁迫的不完全拥挤适应及其渗透细胞的调节作用

IF 3.743 Q2 Biochemistry, Genetics and Molecular Biology

Molecular BioSystems Pub Date : 2017-09-14 DOI:10.1039/C7MB00432J

David Gnutt, Oliver Brylski, Eugen Edengeiser, Martina Havenith and Simon Ebbinghaus

{"title":"哺乳动物细胞对渗透胁迫的不完全拥挤适应及其渗透细胞的调节作用","authors":"David Gnutt, Oliver Brylski, Eugen Edengeiser, Martina Havenith and Simon Ebbinghaus","doi":"10.1039/C7MB00432J","DOIUrl":null,"url":null,"abstract":"<p >Changes of the extracellular milieu could affect cellular crowding. To prevent detrimental effects, cells use adaptation mechanisms to react to such conditions. Using fluorescent crowding sensors, we show that the initial response to osmotic stress is fast but imperfect, while the slow response renders cells more tolerant to stress, particularly in the presence of osmolytes.</p>","PeriodicalId":90,"journal":{"name":"Molecular BioSystems","volume":" 11","pages":" 2218-2221"},"PeriodicalIF":3.7430,"publicationDate":"2017-09-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1039/C7MB00432J","citationCount":"16","resultStr":"{\"title\":\"Imperfect crowding adaptation of mammalian cells towards osmotic stress and its modulation by osmolytes†\",\"authors\":\"David Gnutt, Oliver Brylski, Eugen Edengeiser, Martina Havenith and Simon Ebbinghaus\",\"doi\":\"10.1039/C7MB00432J\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p >Changes of the extracellular milieu could affect cellular crowding. To prevent detrimental effects, cells use adaptation mechanisms to react to such conditions. Using fluorescent crowding sensors, we show that the initial response to osmotic stress is fast but imperfect, while the slow response renders cells more tolerant to stress, particularly in the presence of osmolytes.</p>\",\"PeriodicalId\":90,\"journal\":{\"name\":\"Molecular BioSystems\",\"volume\":\" 11\",\"pages\":\" 2218-2221\"},\"PeriodicalIF\":3.7430,\"publicationDate\":\"2017-09-14\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1039/C7MB00432J\",\"citationCount\":\"16\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Molecular BioSystems\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://pubs.rsc.org/en/content/articlelanding/2017/mb/c7mb00432j\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"Biochemistry, Genetics and Molecular Biology\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Molecular BioSystems","FirstCategoryId":"1085","ListUrlMain":"https://pubs.rsc.org/en/content/articlelanding/2017/mb/c7mb00432j","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"Biochemistry, Genetics and Molecular Biology","Score":null,"Total":0}

引用次数: 16

摘要

细胞外环境的改变可影响细胞拥挤。为了防止有害影响，细胞利用适应机制对这种情况作出反应。利用荧光拥挤传感器，我们发现对渗透胁迫的初始反应是快速但不完美的，而缓慢的反应使细胞更能忍受压力，特别是在渗透细胞存在的情况下。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Imperfect crowding adaptation of mammalian cells towards osmotic stress and its modulation by osmolytes†

查看原文本刊更多论文

Imperfect crowding adaptation of mammalian cells towards osmotic stress and its modulation by osmolytes†

Changes of the extracellular milieu could affect cellular crowding. To prevent detrimental effects, cells use adaptation mechanisms to react to such conditions. Using fluorescent crowding sensors, we show that the initial response to osmotic stress is fast but imperfect, while the slow response renders cells more tolerant to stress, particularly in the presence of osmolytes.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Molecular BioSystems 生物-生化与分子生物学

CiteScore

2.94

自引率

0.00%

发文量

审稿时长

2.6 months

期刊介绍： Molecular Omics publishes molecular level experimental and bioinformatics research in the -omics sciences, including genomics, proteomics, transcriptomics and metabolomics. We will also welcome multidisciplinary papers presenting studies combining different types of omics, or the interface of omics and other fields such as systems biology or chemical biology.