TLE1在滑膜肉瘤中的诊断价值：系统回顾与元分析

Q2 Medicine

Sarcoma Pub Date : 2020-01-29 eCollection Date: 2020-01-01 DOI:10.1155/2020/7192347

Marc El Beaino, Daniel C Jupiter, Tarek Assi, Elie Rassy, Alexander J Lazar, Dejka M Araujo, Patrick P Lin

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引用次数: 0

摘要

背景：滑膜肉瘤在形态上可表现为多种形式，包括双相和单相亚型。因此，组织学诊断有时具有挑战性。转导蛋白样增强子 1（TLE1）是一种转录核心抑制因子，通常参与胚胎发育和造血，但也在某些肿瘤中表达。本系统综述探讨了 TLE1 作为滑膜肉瘤诊断生物标志物的潜在作用。材料与方法。我们使用电子数据库 Pubmed、Cochrane Library 和 Google Scholar 进行了文献综述和荟萃分析。13项研究符合我们的资格标准，并被选中进行深入分析：将所有研究汇总后，TLE1检测滑膜肉瘤的平均灵敏度和特异度分别为94%（95% CI 91%-97%）和81%（95% CI 72%-91%）。TLE1的平均阳性预测值（PPV）为75%（95% CI 62%-87%），而阴性预测值（NPV）为96%（95% CI 93%-98%）：结论：TLE1是滑膜肉瘤敏感而特异的标志物，有助于诊断滑膜肉瘤。结论：TLE1是滑膜肉瘤的敏感性和特异性标志物，可帮助诊断滑膜肉瘤。由于TLE1参与了多个相关的信号通路，它可能与该疾病的病理生理学直接相关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Diagnostic Value of TLE1 in Synovial Sarcoma: A Systematic Review and Meta-Analysis.

查看原文本刊更多论文

Diagnostic Value of TLE1 in Synovial Sarcoma: A Systematic Review and Meta-Analysis.

Background: Synovial sarcoma can present morphologically in multiple forms, including biphasic and monophasic subtypes. As a result, the histological diagnosis can sometimes be challenging. Transducin-Like Enhancer 1 (TLE1) is a transcriptional corepressor that normally is involved in embryogenesis and hematopoiesis but is also expressed in certain tumors. This systematic review examines the potential role of TLE1 as a diagnostic biomarker for the synovial sarcoma. Materials and Methods. A literature review and meta-analysis were conducted using the electronic databases Pubmed, the Cochrane Library, and Google Scholar. Thirteen studies met our eligibility criteria and were selected for in-depth analysis.

Results: The mean sensitivity and specificity of TLE1 in detecting synovial sarcoma were 94% (95% CI 91%-97%) and 81% (95% CI 72%-91%), respectively, when all studies were aggregated together. The mean positive predictive value (PPV) of TLE1 was 75% (95% CI 62%-87%), whereas the negative predictive value (NPV) was 96% (95% CI 93%-98%).

Conclusion: TLE1 is a sensitive and specific marker for synovial sarcoma that can aid in its diagnosis. Due to its involvement in several relevant signaling pathways, TLE1 might have direct relevance to the pathophysiology of the disease.

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来源期刊

Sarcoma Medicine-Radiology, Nuclear Medicine and Imaging

CiteScore

5.00

自引率

0.00%

发文量

审稿时长

14 weeks

期刊介绍： Sarcoma is dedicated to publishing papers covering all aspects of connective tissue oncology research. It brings together work from scientists and clinicians carrying out a broad range of research in this field, including the basic sciences, molecular biology and pathology and the clinical sciences of epidemiology, surgery, radiotherapy and chemotherapy. High-quality papers concerning the entire range of bone and soft tissue sarcomas in both adults and children, including Kaposi"s sarcoma, are published as well as preclinical and animal studies. This journal provides a central forum for the description of advances in diagnosis, assessment and treatment of this rarely seen, but often mismanaged, group of patients.