线粒体复合体II和活性氧在疾病和治疗中的作用。

IF 5.2 2区生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Redox Report Pub Date : 2020-12-01 DOI:10.1080/13510002.2020.1752002

Katerina Hadrava Vanova, Michal Kraus, Jiri Neuzil, Jakub Rohlena

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引用次数: 71

摘要

越来越多的证据表明呼吸复合体II (CII)是活性氧(ROS)的来源和调节剂。CII的功能丧失及其药理抑制均可导致细胞中ROS的产生，并对病理生理状况，即癌症和神经退行性疾病的发生产生相关影响。虽然CII参与活性氧生产的基本框架已经确定，但细节仍有待澄清。解决这些问题对于充分认识CII在病理中的作用，探索其在癌症和其他疾病中的治疗潜力至关重要。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Mitochondrial complex II and reactive oxygen species in disease and therapy.

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Mitochondrial complex II and reactive oxygen species in disease and therapy.

Increasing evidence points to the respiratory Complex II (CII) as a source and modulator of reactive oxygen species (ROS). Both functional loss of CII as well as its pharmacological inhibition can lead to ROS generation in cells, with a relevant impact on the development of pathophysiological conditions, i.e. cancer and neurodegenerative diseases. While the basic framework of CII involvement in ROS production has been defined, the fine details still await clarification. It is important to resolve these aspects to fully understand the role of CII in pathology and to explore its therapeutic potential in cancer and other diseases.

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来源期刊

Redox Report 生物-生化与分子生物学

CiteScore

6.10

自引率

0.00%

发文量

审稿时长

>12 weeks

期刊介绍： Redox Report is a multidisciplinary peer-reviewed open access journal focusing on the role of free radicals, oxidative stress, activated oxygen, perioxidative and redox processes, primarily in the human environment and human pathology. Relevant papers on the animal and plant environment, biology and pathology will also be included. While emphasis is placed upon methodological and intellectual advances underpinned by new data, the journal offers scope for review, hypotheses, critiques and other forms of discussion.