促进氯喹和羟氯喹在2019冠状病毒病(COVID-19)大流行管理中的合理使用的挑战和关注:及时回顾

IF 6.4 2区 医学 Q1 ENVIRONMENTAL SCIENCES
Boscolli Barbosa Pereira
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引用次数: 47

摘要

由于2019年冠状病毒病大流行(COVID-19),全球对治疗的需求迫切。由于其他传染病的处方史、可获得性和相对较低的成本等因素,氯喹(CQ)和羟氯喹(HCQ)在体内和体外进行了抑制致病病毒——严重急性呼吸综合征冠状病毒2 (SARS-CoV-2)的能力测试。然而,即使研究人员注意到这些药物的治疗潜力,重要的是要考虑毒理学风险和合理使用CQ和HCQ的必要护理。本研究提供了使用CQ预防或治疗COVID-19时应考虑的主要毒理学和流行病学方面的信息,但主要是HCQ,它是一种毒性较小的衍生物,根据初步试验显示,HCQ在抑制SARS-CoV-2增殖方面具有更好的效果。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Challenges and cares to promote rational use of chloroquine and hydroxychloroquine in the management of coronavirus disease 2019 (COVID-19) pandemic: a timely review.

As a result of the 2019 coronavirus disease pandemic (COVID-19), there has been an urgent worldwide demand for treatments. Due to factors such as history of prescription for other infectious diseases, availability, and relatively low cost, the use of chloroquine (CQ) and hydroxychloroquine (HCQ) has been tested in vivo and in vitro for the ability to inhibit the causative virus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). However, even though investigators noted the therapeutic potential of these drugs, it is important to consider the toxicological risks and necessary care for rational use of CQ and HCQ. This study provides information on the main toxicological and epidemiological aspects to be considered for prophylaxis or treatment of COVID-19 using CQ but mainly HCQ, which is a less toxic derivative than CQ, and was shown to produce better results in inhibiting proliferation of SARS-CoV-2 based upon preliminary tests.

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来源期刊
CiteScore
13.80
自引率
6.90%
发文量
13
审稿时长
>24 weeks
期刊介绍: "Journal of Toxicology and Environmental Health: Part B - Critical Reviews" is an academic journal published by Taylor & Francis, focusing on the critical examination of research in the areas of environmental exposure and population health. With an ISSN identifier of 1093-7404, this journal has established itself as a significant source of scholarly content in the field of toxicology and environmental health. Since its inception, the journal has published over 424 articles that have garnered 35,097 citations, reflecting its impact and relevance in the scientific community. Known for its comprehensive reviews, the journal also goes by the names "Critical Reviews" and "Journal of Toxicology & Environmental Health, Part B, Critical Reviews." The journal's mission is to provide a platform for in-depth analysis and critical discussion of the latest findings in toxicology, environmental health, and related disciplines. By doing so, it contributes to the advancement of knowledge and understanding of the complex interactions between environmental factors and human health, aiding in the development of strategies to protect and improve public health.
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