脑状态和行为的神经调节。

IF 12.1 1区 医学 Q1 NEUROSCIENCES
Annual review of neuroscience Pub Date : 2020-07-08 Epub Date: 2020-04-06 DOI:10.1146/annurev-neuro-100219-105424
David A McCormick, Dennis B Nestvogel, Biyu J He
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引用次数: 133

摘要

众所周知,神经活动和行为都是多变的,在重复呈现相同的刺激或试验时,反应差异很大。最近对人类和动物的研究结果表明,这些变化在本质上不是随机的,而实际上可能在很大程度上是由于神经、认知和行为状态的快速变化。在这里,我们回顾了最近在清醒状态快速变化的理解方面的进展,变化是如何产生的,以及它们如何调节小鼠和人类的神经和行为反应。我们提出,大脑有一组可识别的状态,通过这些状态,它以一种非随机的方式连续漫游,这是由于上行调节和快速作用的皮质皮质和皮质下神经通路的活动。这些状态变化提供了大脑运作的背景,理解它们对于揭示认知和行为背后的神经机制至关重要。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Neuromodulation of Brain State and Behavior.

Neural activity and behavior are both notoriously variable, with responses differing widely between repeated presentation of identical stimuli or trials. Recent results in humans and animals reveal that these variations are not random in their nature, but may in fact be due in large part to rapid shifts in neural, cognitive, and behavioral states. Here we review recent advances in the understanding of rapid variations in the waking state, how variations are generated, and how they modulate neural and behavioral responses in both mice and humans. We propose that the brain has an identifiable set of states through which it wanders continuously in a nonrandom fashion, owing to the activity of both ascending modulatory and fast-acting corticocortical and subcortical-cortical neural pathways. These state variations provide the backdrop upon which the brain operates, and understanding them is critical to making progress in revealing the neural mechanisms underlying cognition and behavior.

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来源期刊
Annual review of neuroscience
Annual review of neuroscience 医学-神经科学
CiteScore
25.30
自引率
0.70%
发文量
29
期刊介绍: The Annual Review of Neuroscience is a well-established and comprehensive journal in the field of neuroscience, with a rich history and a commitment to open access and scholarly communication. The journal has been in publication since 1978, providing a long-standing source of authoritative reviews in neuroscience. The Annual Review of Neuroscience encompasses a wide range of topics within neuroscience, including but not limited to: Molecular and cellular neuroscience, Neurogenetics, Developmental neuroscience, Neural plasticity and repair, Systems neuroscience, Cognitive neuroscience, Behavioral neuroscience, Neurobiology of disease. Occasionally, the journal also features reviews on the history of neuroscience and ethical considerations within the field.
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