人胰岛素的发现及其结构。

4区医学 Q2 Medicine

Pediatric endocrinology reviews : PER Pub Date : 2020-03-01 DOI:10.17458/per.vol17.2020.zfs.discoverystructureinsulin

Chelsea Zimmerman, Gregory Forlenza, Desmond Schatz

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引用次数: 1

摘要

近100年前，胰岛素的分离和纯化是医学史上最具突破性的发现之一。随后对人胰岛素具体结构的确定使胰岛素配方的进一步发展和修改成为可能，从而提高糖尿病患者的护理质量和生活质量。本文将对胰岛素的结构和生物合成、胰岛素治疗前1型糖尿病的治疗和预后、胰岛素发现的实验以及第一批接受胰岛素治疗的患者进行综述。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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The Discovery and Structure of Human Insulin.

The isolation and purification of insulin nearly 100 years ago has been one of the most ground-breaking discoveries in the history of medicine. Subsequent determination of the specific structure of human insulin has permitted further developments and modifications of the formulations of insulin to allow improved quality of care and quality of life for patients with diabetes. In this paper, we will review insulin structure and biosynthesis, treatment and prognosis of type 1 diabetes prior to insulin therapy, experimentation leading to the discovery of insulin, and the first patients to be treated with insulin.

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来源期刊

Pediatric endocrinology reviews : PER Medicine-Endocrinology, Diabetes and Metabolism

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期刊介绍： PEDIATRIC ENDOCRINOLOGY REVIEWS (PER) publishes scholarly review articles in all areas of clinical and experimental Endocrinology, Diabetes, Nutrition and Metabolism. PER is intended for practicing pediatricians, pediatric endocrinologists, pediatric diabetologists, pediatric gastroenterologists, neonatologists, pediatric gynecologists, nutritionists, sport physicians and pediatricians-in-training. PER will also publish topics on specific subjects or as proceedings of scientific meetings in the above fields of interest. All articles, whether invited or direct contributions, are peer-reviewed. PER publishes correspondence, book reviews, a meeting calendar and meeting reports.