单核细胞计数在精神分裂症和相关疾病中的作用:一项系统综述和荟萃分析。

IF 2.6 4区 医学 Q3 NEUROSCIENCES
Acta Neuropsychiatrica Pub Date : 2020-10-01 Epub Date: 2020-03-17 DOI:10.1017/neu.2020.12
Mario Gennaro Mazza, Martina Capellazzi, Sara Lucchi, Ilaria Tagliabue, Aurora Rossetti, Massimo Clerici
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引用次数: 19

摘要

目的:越来越多的证据表明,免疫和炎症功能障碍可能在精神分裂症及相关精神病的易感性、发病和进展中起重要作用。单核吞噬细胞系统的细胞,特别是小胶质细胞和单核细胞的激活,在精神分裂症中已经有报道。我们进行了这项系统回顾和荟萃分析,以调查健康对照者与精神分裂症及相关疾病患者的单核细胞计数是否存在显著差异。方法:检索主要电子数据库;9例患者符合我们的所有标准,并被纳入meta分析。基于随机效应模型的荟萃分析产生了精神分裂症及相关精神病患者与健康对照者外周血单核细胞计数的汇总标准化平均差异(SMDs)。估计异质性。进行相关敏感性和亚组分析。结果:患者单核细胞计数高于健康对照组(SMD = 0.393;P = 0.001)。各研究的异质性从中等到高(I2 = 65.952%);敏感性分析忽略了两项研究对大多数异质性的影响,结果显示SMD略高。亚组分析证实了这一结果,显示不同研究特征的效应大小没有显著差异。结论:单核细胞计数可被认为是中枢神经系统小胶质细胞激活的间接标志。因此,患者中观察到的较高的单核细胞计数可以被认为是精神分裂症小胶质细胞激活的可能的外周标志物。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Monocyte count in schizophrenia and related disorders: a systematic review and meta-analysis.

Objective: Increasing evidence suggests that immunological and inflammatory dysfunctions may play an important role in predisposition, onset, and progression of schizophrenia and related psychosis. The activation of cells of the mononuclear phagocyte system, especially microglia and monocytes, has been reported in schizophrenia. We carried out this systematic review and meta-analysis to investigate if there are significant differences in monocyte count comparing healthy controls with people suffering from schizophrenia and related disorders.

Methods: We searched main electronic databases; nine records met all our criteria and were included in the meta-analysis. Meta-analyses based on random effects models have been carried out generating pooled standardised mean differences (SMDs) of monocyte count in peripheral blood between schizophrenia and related psychosis and healthy controls. Heterogeneity was estimated. Relevant sensitivity and subgroup analyses were conducted.

Results: Patients showed higher monocyte count as compared with healthy control (SMD = 0.393; p = 0.001). Heterogeneity across studies was from moderate to high (I2 = 65.952%); sensitivity analysis leaving out two studies responsible for most of the heterogeneity showed a slightly higher SMD. Subgroup analyses confirmed this result, showing no significant differences in the effect size across different study characteristics.

Conclusions: Monocyte count can be considered an indirect marker of microglia activation in the central nervous system. Thus, the observed higher monocyte count in patients could be considered as a possible peripheral marker of microglia's activation in schizophrenia disorder.

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来源期刊
Acta Neuropsychiatrica
Acta Neuropsychiatrica NEUROSCIENCES-PSYCHIATRY
自引率
5.30%
发文量
30
期刊介绍: Acta Neuropsychiatrica is an international journal focussing on translational neuropsychiatry. It publishes high-quality original research papers and reviews. The Journal''s scope specifically highlights the pathway from discovery to clinical applications, healthcare and global health that can be viewed broadly as the spectrum of work that marks the pathway from discovery to global health.
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