促鸦片黑素皮质激素神经元与动机运动的转录调控。

IF 4.7 2区医学 Q1 PHYSIOLOGY

Exercise and Sport Sciences Reviews Pub Date : 2020-04-01 DOI:10.1249/JES.0000000000000219

Deborah J Good, Haiyan Zhang, Robert W Grange, Thomas Braun

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引用次数: 4

摘要

下丘脑前鸦片黑素皮质激素(POMC)神经元是能量平衡的关键感觉神经元。基本螺旋-环-螺旋转录因子NHLH2在POMC神经元中表达，NHLH2敲除小鼠表现为成人发病型肥胖，运动行为低。研究人员提出证据，探索POMC神经元内NHLH2转录活性对维持自发活动和强制运动至关重要的假设。

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Pro-opiomelanocortin Neurons and the Transcriptional Regulation of Motivated Exercise.

Hypothalamic pro-opiomelanocortin (POMC) neurons are key sensory neurons for energy balance. The basic helix-loop-helix transcription factor NHLH2 is expressed in POMC neurons, and Nhlh2 knockout mice show adult-onset obesity with low exercise behavior. Evidence is presented to explore the hypothesis that NHLH2 transcriptional activity within POMC neurons is crucial for maintaining motivated spontaneous activity and enforced exercise.

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来源期刊

Exercise and Sport Sciences Reviews 社会科学-生理学

CiteScore

10.70

自引率

1.80%

发文量

期刊介绍： Exercise and Sport Sciences Reviews made the transition from an annual hardcover series book to a quarterly journal in January 2000. The mission of this American College of Sports Medicine publication is to provide premier quarterly reviews of the most contemporary scientific, medical, and research-based topics emerging in the field of sports medicine and exercise science. The publication strives to provide the most relevant, topical information to students, professors, clinicians, scientists, and professionals for practical and research applications.