硫化氢供体胶束保护心肌细胞免于缺血性细胞死亡†

IF 3.743 Q2 Biochemistry, Genetics and Molecular Biology

Molecular BioSystems Pub Date : 2017-06-28 DOI:10.1039/C7MB00191F

T. Takatani-Nakase, M. Katayama, C. Matsui, K. Hanaoka, A. J. van der Vlies, K. Takahashi, I. Nakase and U. Hasegawa

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引用次数: 14

摘要

硫化氢是人体中一种重要的气体信号分子，已知可以保护心肌细胞免受缺血，这是一种以细胞氧气供应不足为特征的疾病。在体外缺血模型中，我们展示了纳米级H2S供体胶束在细胞内释放H2S并阻止心肌细胞凋亡。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Hydrogen sulfide donor micelles protect cardiomyocytes from ischemic cell death†

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Hydrogen sulfide donor micelles protect cardiomyocytes from ischemic cell death†

Hydrogen sulfide, an important gaseous signaling molecule in the human body, is known to protect cardiomyocytes from ischemia, a condition characterized by insufficient oxygen supply to the cells. Here we show that a nanosized H₂S donor micelle releases H₂S intracellularly and prevents cardiomyocyte apoptosis in an in vitro ischemia model.

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来源期刊

Molecular BioSystems 生物-生化与分子生物学

CiteScore

2.94

自引率

0.00%

发文量

审稿时长

2.6 months

期刊介绍： Molecular Omics publishes molecular level experimental and bioinformatics research in the -omics sciences, including genomics, proteomics, transcriptomics and metabolomics. We will also welcome multidisciplinary papers presenting studies combining different types of omics, or the interface of omics and other fields such as systems biology or chemical biology.