[Chemical risks in research laboratories].

Summary: Research laboratories represent peculiar employment realities, generally characterized by the use of reduced volumes of several chemicals, often used in mixture, thus defining a potential exposure to multiple chemical agents. Methods. The aim of the study is to provide a brief review of the most widely used methods for assessing chemical risk in laboratories, with particular emphasis on their limits and advantages. Results. The approach most often used for assessing chemical risk in research laboratories involves the use of a qualitative modeling approach for risk assessment or quantitative exposure assessment tools. Conclusions. Chemical risk assessment algorithms represent a useful solution for the purposes of the initial screening for the assessment of chemical risk in research laboratories: their ease of use makes them easily accessible, but on the other hand does not allow to take into proper consideration the particularities of the assessed exposure scenarios. Regarding the exposure estimation models, although these instruments have a wide range of applicability, there is no solid and complete validation, which evaluates the accuracy and reliability for this peculiar type of exposure scenarios.