神经节细胞:肠-脑感觉传导的新兴生物学。

IF 12.1 1区 医学 Q1 NEUROSCIENCES
Annual review of neuroscience Pub Date : 2020-07-08 Epub Date: 2020-02-26 DOI:10.1146/annurev-neuro-091619-022657
Melanie Maya Kaelberer, Laura E Rupprecht, Winston W Liu, Peter Weng, Diego V Bohórquez
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引用次数: 0

摘要

在视觉、气味、质地和味道的引导下,动物摄取食物。一旦摄入食物,就需要肠道来判断食物的营养价值。传统的感官系统依靠神经上皮回路将刺激转化为指导行为的信号。然而,在发现肠内分泌细胞的突触之前,人们一直认为对肠道环境的感觉只能通过激素的被动释放来实现。这些细胞是肠道感觉上皮细胞,形成突触的细胞被称为神经节细胞。神经节细胞为肠道提供了基础,通过向神经元(包括迷走神经的神经元)的快速神经传递,将肠道环境中的感觉信号传递给大脑。这些发现引发了感觉神经生物学的一个新探索领域--肠道-大脑感觉传导。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Neuropod Cells: The Emerging Biology of Gut-Brain Sensory Transduction.

Guided by sight, scent, texture, and taste, animals ingest food. Once ingested, it is up to the gut to make sense of the food's nutritional value. Classic sensory systems rely on neuroepithelial circuits to convert stimuli into signals that guide behavior. However, sensation of the gut milieu was thought to be mediated only by the passive release of hormones until the discovery of synapses in enteroendocrine cells. These are gut sensory epithelial cells, and those that form synapses are referred to as neuropod cells. Neuropod cells provide the foundation for the gut to transduce sensory signals from the intestinal milieu to the brain through fast neurotransmission onto neurons, including those of the vagus nerve. These findings have sparked a new field of exploration in sensory neurobiology-that of gut-brain sensory transduction.

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来源期刊
Annual review of neuroscience
Annual review of neuroscience 医学-神经科学
CiteScore
25.30
自引率
0.70%
发文量
29
期刊介绍: The Annual Review of Neuroscience is a well-established and comprehensive journal in the field of neuroscience, with a rich history and a commitment to open access and scholarly communication. The journal has been in publication since 1978, providing a long-standing source of authoritative reviews in neuroscience. The Annual Review of Neuroscience encompasses a wide range of topics within neuroscience, including but not limited to: Molecular and cellular neuroscience, Neurogenetics, Developmental neuroscience, Neural plasticity and repair, Systems neuroscience, Cognitive neuroscience, Behavioral neuroscience, Neurobiology of disease. Occasionally, the journal also features reviews on the history of neuroscience and ethical considerations within the field.
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