Kelston Paulo Felice de Sales, Bruno Araújo Serra Pinto, Nathalee Liberal Xavier Ribeiro, Thamys Marinho Melo, Leonardo Victor Galvão-Moreira, Sebastião Barreto de Brito Filho, Flávio Nigri
{"title":"维生素C对大鼠脑缺血再灌注损伤预防作用的实验研究。","authors":"Kelston Paulo Felice de Sales, Bruno Araújo Serra Pinto, Nathalee Liberal Xavier Ribeiro, Thamys Marinho Melo, Leonardo Victor Galvão-Moreira, Sebastião Barreto de Brito Filho, Flávio Nigri","doi":"10.1155/2019/4090549","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Reperfusion syndrome after carotid endarterectomy is a complication associated with cerebrovascular self-regulation in a chronically hypoperfused cerebral hemisphere, leading to severe neurological damage. Vitamin C is an important antioxidant in brain metabolism that has shown some neuroprotective actions.</p><p><strong>Objective: </strong>To investigate the potential effects of vitamin C on cerebral reperfusion in comparison with placebo (saline) in rats.</p><p><strong>Methods: </strong>Male Wistar rats were divided into 3 groups: (i) Sham (<i>n</i> = 4), animals exposed to carotid arteries dissection without clamping; (ii) Control (<i>n</i> = 4), animals exposed to carotid arteries dissection without clamping; (ii) Control (<i>n</i> = 4), animals exposed to carotid arteries dissection without clamping; (ii) Control (.</p><p><strong>Results: </strong>Rats treated with vitamin C presented with a similar behavior as compared to the Sham group in all the three tests (<i>p</i> > 0.05), but it was significantly different from controls (<i>p</i> > 0.05), but it was significantly different from controls (<i>p</i> > 0.05), but it was significantly different from controls (.</p><p><strong>Conclusion: </strong>In the present study, vitamin C was associated with behavioral and motor preservation as well as decreased cerebral MDA levels after induced cerebral ischemia in rats.</p>","PeriodicalId":14448,"journal":{"name":"International Journal of Vascular Medicine","volume":"2019 ","pages":"4090549"},"PeriodicalIF":2.5000,"publicationDate":"2019-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2019/4090549","citationCount":"3","resultStr":"{\"title\":\"Effects of Vitamin C on the Prevention of Ischemia-Reperfusion Brain Injury: Experimental Study in Rats.\",\"authors\":\"Kelston Paulo Felice de Sales, Bruno Araújo Serra Pinto, Nathalee Liberal Xavier Ribeiro, Thamys Marinho Melo, Leonardo Victor Galvão-Moreira, Sebastião Barreto de Brito Filho, Flávio Nigri\",\"doi\":\"10.1155/2019/4090549\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Reperfusion syndrome after carotid endarterectomy is a complication associated with cerebrovascular self-regulation in a chronically hypoperfused cerebral hemisphere, leading to severe neurological damage. Vitamin C is an important antioxidant in brain metabolism that has shown some neuroprotective actions.</p><p><strong>Objective: </strong>To investigate the potential effects of vitamin C on cerebral reperfusion in comparison with placebo (saline) in rats.</p><p><strong>Methods: </strong>Male Wistar rats were divided into 3 groups: (i) Sham (<i>n</i> = 4), animals exposed to carotid arteries dissection without clamping; (ii) Control (<i>n</i> = 4), animals exposed to carotid arteries dissection without clamping; (ii) Control (<i>n</i> = 4), animals exposed to carotid arteries dissection without clamping; (ii) Control (.</p><p><strong>Results: </strong>Rats treated with vitamin C presented with a similar behavior as compared to the Sham group in all the three tests (<i>p</i> > 0.05), but it was significantly different from controls (<i>p</i> > 0.05), but it was significantly different from controls (<i>p</i> > 0.05), but it was significantly different from controls (.</p><p><strong>Conclusion: </strong>In the present study, vitamin C was associated with behavioral and motor preservation as well as decreased cerebral MDA levels after induced cerebral ischemia in rats.</p>\",\"PeriodicalId\":14448,\"journal\":{\"name\":\"International Journal of Vascular Medicine\",\"volume\":\"2019 \",\"pages\":\"4090549\"},\"PeriodicalIF\":2.5000,\"publicationDate\":\"2019-12-15\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1155/2019/4090549\",\"citationCount\":\"3\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"International Journal of Vascular Medicine\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1155/2019/4090549\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2019/1/1 0:00:00\",\"PubModel\":\"eCollection\",\"JCR\":\"Q2\",\"JCRName\":\"PERIPHERAL VASCULAR DISEASE\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"International Journal of Vascular Medicine","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1155/2019/4090549","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2019/1/1 0:00:00","PubModel":"eCollection","JCR":"Q2","JCRName":"PERIPHERAL VASCULAR DISEASE","Score":null,"Total":0}
Effects of Vitamin C on the Prevention of Ischemia-Reperfusion Brain Injury: Experimental Study in Rats.
Background: Reperfusion syndrome after carotid endarterectomy is a complication associated with cerebrovascular self-regulation in a chronically hypoperfused cerebral hemisphere, leading to severe neurological damage. Vitamin C is an important antioxidant in brain metabolism that has shown some neuroprotective actions.
Objective: To investigate the potential effects of vitamin C on cerebral reperfusion in comparison with placebo (saline) in rats.
Methods: Male Wistar rats were divided into 3 groups: (i) Sham (n = 4), animals exposed to carotid arteries dissection without clamping; (ii) Control (n = 4), animals exposed to carotid arteries dissection without clamping; (ii) Control (n = 4), animals exposed to carotid arteries dissection without clamping; (ii) Control (.
Results: Rats treated with vitamin C presented with a similar behavior as compared to the Sham group in all the three tests (p > 0.05), but it was significantly different from controls (p > 0.05), but it was significantly different from controls (p > 0.05), but it was significantly different from controls (.
Conclusion: In the present study, vitamin C was associated with behavioral and motor preservation as well as decreased cerebral MDA levels after induced cerebral ischemia in rats.
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