机械敏感离子通道:与机械转导机制相关的结构特征。

IF 12.1 1区医学 Q1 NEUROSCIENCES

Annual review of neuroscience Pub Date : 2020-07-08 Epub Date: 2020-02-21 DOI:10.1146/annurev-neuro-070918-050509

Peng Jin, Lily Yeh Jan, Yuh-Nung Jan

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引用次数: 115

摘要

机械敏感离子通道的激活是多种需要机械力感觉的基本生理过程的基础。不同的机械敏感通道采用不同的结构和机械转导机制来适应其生物学作用。机械敏感通道是如何工作的，特别是在动物中，在过去的十年中已经被广泛研究。在这里，我们回顾了这些通道的功能和结构特征的主要发现，并强调了与每个特定通道的机械转导机制相关的结构特征。

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Mechanosensitive Ion Channels: Structural Features Relevant to Mechanotransduction Mechanisms.

Activation of mechanosensitive ion channels underlies a variety of fundamental physiological processes that require sensation of mechanical force. Different mechanosensitive channels adapt distinctive structures and mechanotransduction mechanisms to fit their biological roles. How mechanosensitive channels work, especially in animals, has been extensively studied in the past decade. Here we review key findings in the functional and structural characterizations of these channels and highlight the structural features relevant to the mechanotransduction mechanism of each specific channel.

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来源期刊

Annual review of neuroscience 医学-神经科学

CiteScore

25.30

自引率

0.70%

发文量

期刊介绍： The Annual Review of Neuroscience is a well-established and comprehensive journal in the field of neuroscience, with a rich history and a commitment to open access and scholarly communication. The journal has been in publication since 1978, providing a long-standing source of authoritative reviews in neuroscience. The Annual Review of Neuroscience encompasses a wide range of topics within neuroscience, including but not limited to: Molecular and cellular neuroscience, Neurogenetics, Developmental neuroscience, Neural plasticity and repair, Systems neuroscience, Cognitive neuroscience, Behavioral neuroscience, Neurobiology of disease. Occasionally, the journal also features reviews on the history of neuroscience and ethical considerations within the field.