酸中毒中肌肉功能减弱的分子基础:一个建议。

IF 1.8 3区生物学 Q4 CELL BIOLOGY

Journal of Muscle Research and Cell Motility Pub Date : 2020-09-01 Epub Date: 2020-02-11 DOI:10.1007/s10974-020-09576-5

Sherwin S Lehrer

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引用次数: 1

摘要

酸中毒对骨骼肌和心肌的影响提出了一个可测试的分子方案。它是基于1974年发表的荧光研究，该研究提供了EF-hand Ca2+结合位点的羧酸盐具有异常pKa的证据。这导致3状态肌肉调节模型中的H+结合阻断亚状态，其作用是在pH 7至6范围内抑制肌球蛋白结合。一幅图解说明了三状态模型中的子状态。

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The molecular basis for diminished muscle function in acidosis: a proposal.

A testable molecular proposal for the effects of acidosis on skeletal and cardiac muscle is presented. It is based on fluorescence studies published in 1974, which provided evidence for carboxylates in an EF-hand Ca²⁺ binding site having an abnormal pKa. This results in an H⁺-bound Blocked substate in the 3-state model of muscle regulation whose contribution inhibits myosin binding in the pH 7 to 6 range. A schematic cartoon illustrates the substate within the 3-state model.

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来源期刊

Journal of Muscle Research and Cell Motility 生物-细胞生物学

CiteScore

6.20

自引率

0.00%

发文量

审稿时长

>12 weeks

期刊介绍： The Journal of Muscle Research and Cell Motility has as its main aim the publication of original research which bears on either the excitation and contraction of muscle, the analysis of any one of the processes involved therein, the processes underlying contractility and motility of animal and plant cells, the toxicology and pharmacology related to contractility, or the formation, dynamics and turnover of contractile structures in muscle and non-muscle cells. Studies describing the impact of pathogenic mutations in genes encoding components of contractile structures in humans or animals are welcome, provided they offer mechanistic insight into the disease process or the underlying gene function. The policy of the Journal is to encourage any form of novel practical study whatever its specialist interest, as long as it falls within this broad field. Theoretical essays are welcome provided that they are concise and suggest practical ways in which they may be tested. Manuscripts reporting new mutations in known disease genes without validation and mechanistic insight will not be considered. It is the policy of the journal that cells lines, hybridomas and DNA clones should be made available by the developers to any qualified investigator. Submission of a manuscript for publication constitutes an agreement of the authors to abide by this principle.