一种含有乳酸乳球菌亚种的补剂的剂量测定研究。有轻度便秘的健康成人的cremoris FC。

IF 3.1 4区医学 Q2 Agricultural and Biological Sciences

Bioscience of Microbiota, Food and Health Pub Date : 2020-01-01 Epub Date: 2019-09-10 DOI:10.12938/bmfh.19-009

Yayoi Gotoh, Fumio Nanba, Nobuhiko Shioya, Haruhi Sugimura, Toshio Suzuki

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引用次数: 3

摘要

为确定乳酸乳球菌亚种的有效剂量，进行了剂量递增研究。cremoris FC改善健康受试者的排便。招募了27名受试者，并连续摄入安慰剂和两个剂量水平的火烈性乳杆菌FC(剂量水平1,1 × 107 cfu;剂量水平2，每天2 × 107 cfu)胶囊，持续两周。剂量水平2显著增加排便次数(次/周)，剂量水平1显著增加排便量(单位/周)。这项剂量递增研究表明，摄入至少1 × 107 cfu的乳化菌FC可改善排便。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

A dose-finding study for a supplement containing Lactococcus lactis subsp. cremoris FC in healthy adults with mild constipation.

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A dose-finding study for a supplement containing Lactococcus lactis subsp. cremoris FC in healthy adults with mild constipation.

A dose-escalation study was conducted to find the effective dose of Lactococcus lactis subsp. cremoris FC for improving defecation in healthy subjects. Twenty-seven subjects were recruited and consecutively ingested a placebo and two dose levels of L. cremoris FC (dose level 1, 1 × 10⁷ cfu; dose level 2, 2 × 10⁷ cfu) capsules daily for two weeks. Frequency of defecation (times/week) was significantly increased by dose level 2, and stool volume (units/week) was significantly increased by dose level 1. This dose-escalation study elucidated that intake of at least 1 × 10⁷ cfu L. cremoris FC improves defecation.

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来源期刊

Bioscience of Microbiota, Food and Health Immunology and Microbiology-Applied Microbiology and Biotechnology

CiteScore

5.50

自引率

3.20%

发文量

期刊介绍： Bioscience of Microbiota, Food and Health (BMFH) is a peer-reviewed scientific journal with a specific area of focus: intestinal microbiota of human and animals, lactic acid bacteria (LAB) and food immunology and food function. BMFH contains Full papers, Notes, Reviews and Letters to the editor in all areas dealing with intestinal microbiota, LAB and food immunology and food function. BMFH takes a multidisciplinary approach and focuses on a broad spectrum of issues.